CAR Activators
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
TCPOBOP | 76150-91-9 | sc-203291 | 25 mg | $209.00 | 4 | |
TCPOBOP functions as a potent chemical activator, exhibiting unique interactions with target proteins through its electrophilic nature. Its reactivity is characterized by rapid acylation of nucleophilic sites, leading to distinct pathways in cellular signaling. The compound's steric properties enhance selectivity, allowing for precise modulation of enzymatic activity. Additionally, its stability under various conditions makes it a versatile tool for probing biochemical mechanisms and reaction kinetics. | ||||||
Scoparone | 120-08-1 | sc-202806 | 25 mg | $109.00 | 1 | |
Scoparone acts as a selective chemical modulator, engaging in specific interactions with biomolecules through its unique structural features. Its ability to form stable complexes with target sites facilitates distinct regulatory pathways, influencing cellular processes. The compound's hydrophobic characteristics enhance membrane permeability, allowing for efficient distribution within biological systems. Furthermore, its reactivity profile showcases a balance between stability and reactivity, making it an intriguing subject for studying molecular dynamics. | ||||||
PK 11195 | 85532-75-8 | sc-203199 sc-203199A | 10 mg 50 mg | $88.00 $321.00 | ||
PK 11195 is a selective ligand that exhibits unique binding affinity for the translocator protein, influencing mitochondrial functions. Its distinct structural conformation allows for specific interactions that modulate cellular signaling pathways. The compound's lipophilic nature enhances its ability to traverse lipid membranes, promoting effective localization within cellular compartments. Additionally, its kinetic behavior reveals a nuanced balance between rapid association and slower dissociation, providing insights into receptor dynamics. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin, an antibiotic, is a direct activator of CAR, binding to its ligand-binding domain and inducing a conformational change that enhances CAR transactivation. This direct activation results in the upregulation of CAR-dependent genes, impacting drug metabolism and xenobiotic response pathways. Rifampicin's ability to activate CAR highlights its role in modulating hepatic drug metabolism and xenobiotic response elements. | ||||||
CITCO | 338404-52-7 | sc-202544 sc-202544A | 5 mg 25 mg | $84.00 $312.00 | 4 | |
CITCO (6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime), a specific CAR agonist, directly activates CAR by binding to its ligand-binding domain, promoting CAR transactivation. This direct activation induces the expression of CAR-responsive genes, influencing drug metabolism and xenobiotic response pathways. | ||||||
BDE No 47 solution | 5436-43-1 | sc-233922 | 1 ml | $306.00 | ||
PBDE-47 (2,2',4,4'-Tetrabromodiphenyl ether), an environmental pollutant, indirectly activates CAR by influencing the aryl hydrocarbon receptor (AhR) pathway. PBDE-47 activates AhR, leading to the induction of CYP2B6, a CAR-responsive gene. This indirect activation highlights the crosstalk between AhR and CAR signaling pathways, suggesting a potential role for environmental pollutants in modulating CAR activity and hepatic drug metabolism. | ||||||
6-Formylindolo[3,2-b]carbazole | 172922-91-7 | sc-300019A sc-300019 | 100 µg 5 mg | $105.00 $2185.00 | 5 | |
6-Formylindolo[3,2-b]carbazole, an AhR agonist, indirectly activates CAR by modulating the AhR pathway. Activation of AhR by 6-Formylindolo[3,2-b]carbazole leads to the induction of CAR-responsive genes, impacting drug metabolism and xenobiotic response pathways. This indirect activation reveals the interconnectedness between AhR and CAR signaling and suggests a potential avenue for modulating CAR activity through the regulation of AhR signaling pathways. | ||||||
Triclocarban | 101-20-2 | sc-213106 | 100 mg | $260.00 | 1 | |
TCC (3,3',4,4'-Tetrachlorocarbanilide), an antimicrobial agent, indirectly activates CAR by influencing the constitutive androstane receptor (CAR) pathway. TCC activates CAR, leading to the induction of CAR-responsive genes involved in drug metabolism and xenobiotic response. This indirect activation highlights the potential impact of antimicrobial agents on CAR activity and suggests a role for TCC in modulating hepatic drug metabolism through CAR-dependent mechanisms. | ||||||
β-Naphthoflavone | 6051-87-2 | sc-205597 sc-205597A sc-205597B sc-205597C | 1 g 5 g 25 g 100 g | $33.00 $129.00 $599.00 $1647.00 | 2 | |
β-Naphthoflavone, an AhR agonist, indirectly activates CAR by modulating the AhR pathway. Activation of AhR by β-Naphthoflavone leads to the induction of CAR-responsive genes, influencing drug metabolism and xenobiotic response pathways. This indirect activation underscores the interconnectedness between AhR and CAR signaling, providing insights into potential mechanisms for modulating CAR activity through the regulation of AhR signaling pathways. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole, a proton pump inhibitor, indirectly activates CAR by modulating the pregnane X receptor (PXR) pathway. Omeprazole activates PXR, leading to the induction of CAR-responsive genes involved in drug metabolism and xenobiotic response. This indirect activation highlights the crosstalk between PXR and CAR signaling pathways, suggesting a potential role for proton pump inhibitors in modulating CAR activity and hepatic drug metabolism. | ||||||