Molecular structure of PK 11195, CAS Number: 85532-75-8
PK 11195 (CAS 85532-75-8)
Alternate Names:
1-(2-Chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinolinecarboxamide
Application:
PK 11195 is a peripheral benzodiazepine antagonist
CAS Number:
85532-75-8
Purity:
≥98%
Molecular Weight:
352.9
Molecular Formula:
C21H21ClN2O
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PK 11195 is a peripheral benzodiazepine receptor (PBR) antagonist. The compound has been shown to help elicit the δPsim disruption and induce apoptosis. Furthermore, studies report that the apoptotic inhibition of activity of Bcl-2 is blocked by PK 1195 through its affect on the mitochondia. PK 11195 is also an activator of CAR.
PK 11195 (CAS 85532-75-8) References
- The pharmacodynamics of PK 11195 in diazepam-dependent male and female rats. | Sloan, JW., et al. 2000. Pharmacol Biochem Behav. 66: 751-64. PMID: 10973513
- Pharmacokinetics and effects on exercise heart rate of PK 11195 (52028 RP), an antagonist of peripheral benzodiazepine receptors, in healthy volunteers. | Ferry, A., et al. 1989. Fundam Clin Pharmacol. 3: 383-92. PMID: 2553568
- Differential binding properties of the peripheral-type benzodiazepine ligands [3H]PK 11195 and [3H]Ro 5-4864 in trout and mouse brain membranes. | Eshleman, AJ. and Murray, TF. 1989. J Neurochem. 53: 494-502. PMID: 2746235
- PK 11195, an antagonist of peripheral benzodiazepine receptors, reduces ventricular arrhythmias during myocardial ischemia and reperfusion in the dog. | Mestre, M., et al. 1985. Eur J Pharmacol. 112: 257-60. PMID: 2992998
- The Protective Effect of PK-11195 on Cognitive Impairment in Rats Survived of Polymicrobial Sepsis. | Dominguini, D., et al. 2021. Mol Neurobiol. 58: 2724-2733. PMID: 33495933
- The Effect of the Classical TSPO Ligand PK 11195 on In Vitro Cobalt Chloride Model of Hypoxia-like Condition in Lung and Brain Cell Lines. | Amara, R., et al. 2022. Biomolecules. 12: PMID: 36291606
- Differentiation between two ligands for peripheral benzodiazepine binding sites, [3H]RO5-4864 and [3H]PK 11195, by thermodynamic studies. | Le Fur, G., et al. 1983. Life Sci. 33: 449-57. PMID: 6308375
- PK 11195 aggravates 3,5-diethoxycarbonyl-1,4-dihydrocollidine-induced hepatic porphyria in rats. | Fonia, O., et al. 1996. Hepatology. 24: 697-701. PMID: 8781345
- PK 11195 antagonizes the positive inotropic response of the isolated rat heart to diazepam but not the negative inotropic response. | Leeuwin, RS., et al. 1996. Eur J Pharmacol. 299: 149-52. PMID: 8901017
- PK11195, a ligand of the mitochondrial benzodiazepine receptor, facilitates the induction of apoptosis and reverses Bcl-2-mediated cytoprotection. | Hirsch, T., et al. 1998. Exp Cell Res. 241: 426-34. PMID: 9637784
Inhibitor of:
HNF-4γ, PBR, TSPO2, and TXNL1.Activator of:
CAR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PK 11195, 10 mg | sc-203199 | 10 mg | $88.00 | |||
PK 11195, 50 mg | sc-203199A | 50 mg | $321.00 |