Molecular structure of Scoparone, CAS Number: 120-08-1
Scoparone (CAS 120-08-1)
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Alternate Names:
6,7-Dimethylesculetin, 6,7-Dimethoxycoumarin
Application:
Scoparone is an agent that can up-regulate the expression and activate CAR
CAS Number:
120-08-1
Purity:
≥98%
Molecular Weight:
206.20
Molecular Formula:
C11H10O4
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Scoparone is a compound found in the herb, Yin Chin, that can up-regulate the expression and activate the constitutive androstane receptor (CAR) found in the liver. It has been shown to clear the accumulation of bilirubin by the activation of CAR in neonatal jaundice. Other studies show that scaparone inhibits lipopolysaccharide (LPS)-induced tissue factor (TF) expression in HUVECs and that it acts as an anti-inflammatory compound. TCPOBOP also transactivates CAR, however, scoparone can activate murine and human CAR. Scaparone can increase dopamine release by synapsin I phosphorylation through activation of PKA and CaMK II in PC12 cells. It can also activate neurite outgrowth and improve dopamine biosynthesis in PC12 cells.
Scoparone (CAS 120-08-1) References
- Transcriptional activation of cytochrome P450 CYP2C45 by drugs is mediated by the chicken xenobiotic receptor (CXR) interacting with a phenobarbital response enhancer unit. | Baader, M., et al. 2002. J Biol Chem. 277: 15647-53. PMID: 11867618
- Scoparone inhibits tissue factor expression in lipopolysaccharide-activated human umbilical vein endothelial cells. | Lee, YM., et al. 2003. J Biomed Sci. 10: 518-25. PMID: 12928592
- East meets West: an herbal tea finds a receptor. | Lazar, MA. 2004. J Clin Invest. 113: 23-5. PMID: 14702104
- A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR. | Huang, W., et al. 2004. J Clin Invest. 113: 137-43. PMID: 14702117
- Stimulation of melanogenesis by scoparone in B16 melanoma cells. | Yang, JY., et al. 2006. Acta Pharmacol Sin. 27: 1467-73. PMID: 17049123
- Effect of scoparone on neurite outgrowth in PC12 cells. | Yang, YJ., et al. 2008. Neurosci Lett. 440: 14-8. PMID: 18547723
- Effects of scoparone on dopamine biosynthesis and L-DOPA-induced cytotoxicity in PC12 cells. | Yang, YJ., et al. 2009. J Neurosci Res. 87: 1929-37. PMID: 19185027
- Effects of scoparone on dopamine release in PC12 cells. | Yang, YJ., et al. 2010. Fitoterapia. 81: 497-502. PMID: 20080157
- Scoparone inhibits adipocyte differentiation through down-regulation of peroxisome proliferators-activated receptor γ in 3T3-L1 preadipocytes. | Noh, JR., et al. 2013. Food Chem. 141: 723-30. PMID: 23790840
- Scoparone Protects Against Pancreatic Fibrosis via TGF-β/Smad Signaling in Rats. | Xu, M., et al. 2016. Cell Physiol Biochem. 40: 277-286. PMID: 27855406
- Scoparone prevents IL-1β-induced inflammatory response in human osteoarthritis chondrocytes through the PI3K/Akt/NF-κB pathway. | Lu, C., et al. 2018. Biomed Pharmacother. 106: 1169-1174. PMID: 30119184
- Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in mice. | Liu, B., et al. 2019. Int Immunopharmacol. 75: 105797. PMID: 31421545
- Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS/P38/Nrf2 axis and PI3K/AKT/mTOR pathway in macrophages. | Liu, B., et al. 2020. Biomed Pharmacother. 125: 109895. PMID: 32000066
- Scoparone alleviates Ang II-induced pathological myocardial hypertrophy in mice by inhibiting oxidative stress. | Lyu, L., et al. 2021. J Cell Mol Med. 25: 3136-3148. PMID: 33560596
- Neuropsychopharmacological profiling of scoparone in mice. | Kowalczyk, J., et al. 2022. Sci Rep. 12: 822. PMID: 35039558
Activator of:
CAR.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Scoparone, 25 mg | sc-202806 | 25 mg | $109.00 |