Date published: 2025-12-20

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CAP-G2 Inhibitors

CAP-G2 Inhibitors are a specialized class of chemical compounds designed to impede the activity of the CAP-G2 protein, a protein implicated in various cellular processes. These inhibitors exert their effects by targeting the specific biological pathways and molecular interactions where CAP-G2 is involved. The inhibition can occur either through direct binding to the CAP-G2 protein, thereby altering its conformation and function, or indirectly by modulating the activity of other proteins or enzymes that regulate CAP-G2's function. These compounds may affect various signaling pathways such as those responsible for cell division, signal transduction, or the transport and translation of genetic material, where CAP-G2 plays a pivotal role. The specificity of CAP-G2 Inhibitors lies in their ability to selectively bind or alter the activity of CAP-G2 without significantly affecting other proteins, ensuring that the inhibition is targeted and the downstream effects are predictable.

The molecular design of CAP-G2 Inhibitors often includes motifs that mimic the natural substrates or binding partners of CAP-G2, ensuring a high affinity and specificity for the target protein. By binding to the active or allosteric sites of CAP-G2, these inhibitors can prevent the protein from performing its normal function, which is typically essential for the maintenance of cellular homeostasis. Some CAP-G2 Inhibitors may also work by destabilizing the protein or promoting its degradation. The precise mechanism of action for each inhibitor varies, but the commonality among them is the resulting decrease in CAP-G2 activity. This inhibition can lead to an accumulation or reduction of specific cellular components or signals that CAP-G2 usually regulates, thereby impacting the cellular processes in which CAP-G2 is a key player. The biochemical action of these inhibitors is a subject of interest for researchers aiming to understand the intricate web of cellular signaling and regulation.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Staurosporine

62996-74-1sc-3510
sc-3510A
sc-3510B
100 µg
1 mg
5 mg
$82.00
$150.00
$388.00
113
(4)

A potent kinase inhibitor known to affect a wide range of kinases. It interferes with the ATP-binding site of kinases, which could lead to the inhibition of the phosphorylation processes essential for CAP-G2 function.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

A phosphatidylinositol 3-kinase (PI3K) inhibitor that can prevent phosphorylation and activation of downstream proteins that may be necessary for CAP-G2-mediated signaling pathways.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

An mTOR inhibitor which can suppress the mTOR pathway, a signaling pathway that could be involved in the regulation of CAP-G2, leading to its functional inhibition.

Cyclosporin A

59865-13-3sc-3503
sc-3503-CW
sc-3503A
sc-3503B
sc-3503C
sc-3503D
100 mg
100 mg
500 mg
10 g
25 g
100 g
$62.00
$90.00
$299.00
$475.00
$1015.00
$2099.00
69
(5)

An immunosuppressant that binds to the cyclophilins and inhibits calcineurin. By inhibiting calcineurin, it could reduce the dephosphorylation and activation of NFAT, which may indirectly decrease CAP-G2 activity if it is modulated by NFAT.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

A histone deacetylase inhibitor that can alter gene expression. By changing chromatin structure, it may downregulate genes required for CAP-G2 activation or expression.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

An inhibitor of MEK1/2, which inhibits the MAPK/ERK pathway. Disruption of this pathway could lead to downregulation of CAP-G2 if it is dependent on this signaling for its activation.

Bortezomib

179324-69-7sc-217785
sc-217785A
2.5 mg
25 mg
$132.00
$1064.00
115
(2)

A proteasome inhibitor which can lead to the accumulation of proteins marked for degradation. This could indirectly affect CAP-G2 stability and function if it is regulated by proteasomal degradation.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

Another MEK inhibitor that prevents the activation of MAPK/ERK pathway. Similar to U0126, it could decrease the activity of CAP-G2 by inhibiting the signaling pathway necessary for its function.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

A p38 MAPK inhibitor that can block the p38 signaling pathway. If CAP-G2 is activated or stabilized by p38 MAPK, this inhibitor could lead to its functional decrease.

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

A PI3K inhibitor that acts irreversibly and could diminish the activation of downstream targets relevant to CAP-G2 function.