calsyntenin-3 Inhibitors
Calsyntenin-3, a member of the calsyntenin family, is a neuronal cadherin-related protein that plays a pivotal role in the molecular dynamics of neural cells and synaptic function. Characterized by its involvement in the formation and maintenance of synaptic connections, calsyntenin-3 contributes to the intricate web of signaling that underpins neural communication and plasticity. As a transmembrane protein, it is integrated within the cellular architecture of neurons, facilitating interactions both within the cell and across the synaptic cleft. The expression of calsyntenin-3 is tightly regulated within the central nervous system, reflecting its significance in maintaining the delicate balance of neural activity. Given its foundational role in synaptic operations, the precise modulation of calsyntenin-3 levels is a subject of considerable interest, especially regarding the mechanisms that govern its expression.
The regulation of calsyntenin-3 expression can be influenced by various chemical compounds, which, while not directly targeting the protein itself, can modulate its production at the transcriptional or translational level. Certain compounds can downregulate calsyntenin-3 by altering chromatin structure, affecting gene accessibility and the binding of transcription factors. Other chemicals may modify the methylation status of the gene's promoter region, indirectly leading to a reduction in gene expression. Some compounds that interfere with DNA replication and repair can also impact the transcription levels of calsyntenin-3 by causing DNA damage, which must be repaired before normal gene expression can resume. Additionally, inhibitors of RNA synthesis can reduce the overall mRNA output for calsyntenin-3, while other agents may decrease the translation of proteins that regulate its expression. These varied mechanisms demonstrate the complexity of cellular regulation and the multiple ways in which chemical intervention can affect gene expression pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor could downregulate calsyntenin-3 by increasing the acetylation of histones, leading to a more open chromatin structure and altered transcription factor binding at the gene's promoter. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine may reduce calsyntenin-3 expression by promoting demethylation of its promoter region, thereby decreasing binding affinity of methylation-sensitive repressor proteins. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
By binding to G-C rich regions of DNA, Mithramycin A could specifically downregulate calsyntenin-3 by blocking transcriptional initiation at its promoter, leading to reduced mRNA synthesis. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This compound may inhibit calsyntenin-3 transcription by intercalating into DNA at transcription initiation complexes, obstructing the elongation phase of mRNA synthesis. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin could decrease calsyntenin-3 expression by intercalating into DNA and disrupting the function of topoisomerase II, leading to DNA breaks and halting transcriptional processes. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine may downregulate calsyntenin-3 by intercalating into the gene's DNA, obstructing the binding of transcription factors and RNA polymerase necessary for gene expression. | ||||||
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $260.00 $1029.00 | 26 | |
This selective inhibitor of RNA polymerase II could decrease calsyntenin-3 levels by halting the transcriptional elongation of its primary transcripts, leading to reduced mRNA availability for translation. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin may inhibit calsyntenin-3 by stabilizing the covalent complex between topoisomerase I and DNA during transcription, inducing DNA breaks and preventing the advancement of RNA polymerase. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
This compound could downregulate calsyntenin-3 by activating retinoic acid receptors that bind to retinoic acid response elements in the promoter region of the gene, altering the expression of secondary regulators that control calsyntenin-3 gene transcription. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone may reduce calsyntenin-3 expression by activating glucocorticoid receptors, which may bind to glucocorticoid response elements in the promoter region of the gene or interact with other transcription factors that control calsyntenin-3 expression. | ||||||