CALML5 Activators
CALML5 Activators represent a class of chemical compounds that can enhance the function of CALML5 through various specific biochemical and cellular pathways. These compounds affect key aspects of the protein's function, such as its role in protein folding and its interaction with calcium ions. Anisomycin and Tunicamycin act on the JNK signaling pathway and N-linked glycosylation process, respectively. The activation of the JNK pathway by Anisomycin can enhance CALML5's functional activity due to its interaction with proteins involved in this pathway. The inhibition of N-linked glycosylation by Tunicamycin leads to increased demand for CALML5's glycosylation activity. Forskolin and IBMX enhance CALML5 function indirectly by increasing levels of cyclic AMP, which is involved in protein folding regulation. Increasing the demand for protein folding enhances the functional activity of CALML5, a known chaperone protein.
On the other hand, A23187, Thapsigargin, 2-APB, Dantrolene, Phenylephrine, Verapamil, Cyclopiazonic Acid, and Ryanodine all work through manipulating calcium ion levels or availability. CALML5 is a calcium-binding protein, and so, by increasing the availability of calcium, these chemicals can enhance CALML5's functional activity. For instance, A23187 and Thapsigargin increase intracellular calcium levels, and 2-APB, Dantrolene, and Verapamil increase calcium concentration in the Endoplasmic Reticulum where CALML5 is located. Phenylephrine triggers the release of intracellular calcium, whereas Cyclopiazonic Acid and Ryanodine modify specific receptors to increase cytosolic calcium levels. Such alterations in calcium ion dynamics effectively enhance the functional activity of CALML5.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates the JNK signaling pathway. CALML5 has been found to interact with proteins involved in this pathway, suggesting that Anisomycin can enhance the functional activity of CALML5 by activating the JNK pathway. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, a post-translational modification that CALML5 is known to facilitate. By inhibiting this process, Tunicamycin can enhance the functional activity of CALML5 by increasing the demand for its glycosylation activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. Since CALML5 is a calcium-binding protein, A23187 could enhance the functional activity of CALML5 by increasing the availability of its calcium substrate. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin is an activator of adenylate cyclase, leading to increased levels of cyclic AMP. As cAMP is involved in the regulation of protein folding, Forskolin could enhance the functional activity of CALML5, a chaperone protein, by increasing the demand for protein folding. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases (PDEs), which degrade cAMP. By increasing cAMP levels, IBMX could enhance the functional activity of CALML5 by increasing the demand for protein folding. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to increased cytosolic calcium levels. As CALML5 is a calcium-binding protein, Thapsigargin could enhance the functional activity of CALML5 by increasing the availability of its calcium substrate. | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $27.00 $52.00 | 37 | |
2-APB is an inhibitor of IP3 receptors, which are involved in the release of calcium from the ER. By inhibiting IP3 receptors, 2-APB could enhance the functional activity of CALML5 by increasing the concentration of calcium in the ER, where CALML5 resides. | ||||||
Dantrolene | 7261-97-4 | sc-500165 | 25 mg | $350.00 | 7 | |
Dantrolene inhibits ryanodine receptors, which are involved in the release of calcium from the sarcoplasmic reticulum. By inhibiting these receptors, Dantrolene could enhance the functional activity of CALML5 by increasing the concentration of calcium in the ER, where CALML5 is located. | ||||||
L-phenylephrine | 59-42-7 | sc-295315 sc-295315A | 5 g 25 g | $177.00 $482.00 | 2 | |
Phenylephrine is an alpha-1 adrenergic receptor agonist, which triggers the release of intracellular calcium. Since CALML5 is a calcium-binding protein, Phenylephrine could enhance the functional activity of CALML5 by increasing the availability of its calcium substrate. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is an inhibitor of voltage-gated calcium channels. By inhibiting these channels, Verapamil could enhance the functional activity of CALML5 by increasing the concentration of calcium in the ER, where CALML5 is located. | ||||||