CALML5 Antibody (A-3): sc-393637
- CALML5 Antibody (A-3) is a mouse monoclonal IgG2a κ CALML5 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1-124 mapping at the N-terminus of CALML5 of human origin
- CALML5 Antibody (A-3) is recommended for detection of CALML5 of human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-CALML5 Antibody (A-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP is the preferred secondary detection reagent for CALML5 Antibody (A-3) for WB and IHC(P) applications. This reagent is now offered in a bundle with CALML5 Antibody (A-3) (see ordering information below).
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CALML5 Antibody (A-3) is a mouse monoclonal IgG2a kappa light chain antibody that detects CALML5 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). CALML5 (A-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. CALML5, also known as calmodulin-like 5 or CLSP, is a 146 amino acid protein characterized by four EF-hand domains, which are critical for calcium binding. This structural feature enables CALML5 to function similarly to calmodulin, acting as a calcium sensor that modulates various cellular processes. CALML5 is predominantly expressed in the epidermis, where CALML5 plays a significant role in the terminal differentiation of keratinocytes. CALML5 interacts with transglutaminase 3 (TGase3), a key enzyme involved in the cross-linking of proteins during skin barrier formation, highlighting CALML5′s importance in maintaining skin integrity and function. Through calcium level regulation and protein interactions, CALML5 contributes to vital physiological processes, making CALML5 a valuable target for research in skin biology and related fields.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CALML5 Antibody (A-3) References:
- Calmodulin-like skin protein: a new marker of keratinocyte differentiation. | Méhul, B., et al. 2001. J Invest Dermatol. 116: 905-9. PMID: 11407979
- Human calmodulin-like protein is an epithelial-specific protein regulated during keratinocyte differentiation. | Rogers, MS., et al. 2001. Exp Cell Res. 267: 216-24. PMID: 11426940
- Cation- and peptide-binding properties of human calmodulin-like skin protein. | Durussel, I., et al. 2002. Biochemistry. 41: 5439-48. PMID: 11969404
- Characterization of the human calmodulin-like protein expressed in Escherichia coli. | Rhyner, JA., et al. 1992. Biochemistry. 31: 12826-32. PMID: 1334432
- Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis. | Méhul, B., et al. 2006. Exp Dermatol. 15: 469-77. PMID: 16689864
- A structural and dynamic characterization of the EF-hand protein CLSP. | Babini, E., et al. 2006. Structure. 14: 1029-38. PMID: 16765896
- Down-regulation of a calmodulin-related gene during transformation of human mammary epithelial cells. | Yaswen, P., et al. 1990. Proc Natl Acad Sci U S A. 87: 7360-4. PMID: 2217169
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CALML5 Antibody (A-3) | sc-393637 | 200 µg/ml | $316.00 | |||
CALML5 Antibody (A-3): m-IgG2a BP-HRP Bundle | sc-545967 | 200 µg Ab; 10 µg BP | $354.00 | |||
CALML5 Antibody (A-3) AC | sc-393637 AC | 500 µg/ml, 25% agarose | $416.00 | |||
CALML5 Antibody (A-3) HRP | sc-393637 HRP | 200 µg/ml | $316.00 | |||
CALML5 Antibody (A-3) FITC | sc-393637 FITC | 200 µg/ml | $330.00 | |||
CALML5 Antibody (A-3) PE | sc-393637 PE | 200 µg/ml | $343.00 | |||
CALML5 Antibody (A-3) Alexa Fluor® 488 | sc-393637 AF488 | 200 µg/ml | $357.00 | |||
CALML5 Antibody (A-3) Alexa Fluor® 546 | sc-393637 AF546 | 200 µg/ml | $357.00 | |||
CALML5 Antibody (A-3) Alexa Fluor® 594 | sc-393637 AF594 | 200 µg/ml | $357.00 | |||
CALML5 Antibody (A-3) Alexa Fluor® 647 | sc-393637 AF647 | 200 µg/ml | $357.00 | |||
CALML5 Antibody (A-3) Alexa Fluor® 680 | sc-393637 AF680 | 200 µg/ml | $357.00 | |||
CALML5 Antibody (A-3) Alexa Fluor® 790 | sc-393637 AF790 | 200 µg/ml | $357.00 |