Date published: 2026-4-28

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Calcyon Activators

Calcyon activators belong to a class of chemical compounds designed to modulate the activity of Calcyon, a neuron-specific protein also known as Dopamine and cAMP-Regulated Neuronal Phosphoprotein 32 (DARPP-32). Calcyon is primarily expressed in neurons of the central nervous system and has garnered significant attention for its involvement in synaptic transmission, neural plasticity, and the regulation of dopamine signaling. As a key component of the striatal medium spiny neurons, Calcyon plays a pivotal role in integrating signals from various neurotransmitters, including dopamine, glutamate, and GABA, which are crucial for motor control, reward, and cognition.

Calcyon activators are engineered to interact with Calcyon, potentially influencing its signaling pathways and neuronal functions. These compounds may modulate Calcyon's phosphorylation states and interactions with other signaling molecules, thereby impacting synaptic transmission and plasticity. Research on Calcyon activators offers insights into the complex mechanisms governing neuronal communication and the regulation of dopamine-related pathways. Understanding the molecular interactions between Calcyon and its activators is essential for unraveling the intricate processes that underlie brain function and behavior. Further investigation is necessary to elucidate the precise mechanisms of action and potential biological consequences associated with Calcyon activation, contributing to our knowledge of neurobiology and neurotransmitter regulation in the brain.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$78.00
$153.00
$740.00
$1413.00
$2091.00
73
(3)

Forskolin activates adenylyl cyclase, increasing cAMP levels, which can upregulate genes involved in neuronal function and possibly increase Calcyon expression.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$41.00
$132.00
$214.00
$500.00
$948.00
119
(6)

PMA activates protein kinase C (PKC) and can mimic diacylglycerol; it may upregulate Calcyon expression as part of the PKC signaling pathway.

Kainic acid monohydrate

58002-62-3sc-269283
10 mg
$275.00
(1)

Kainic acid is an agonist of glutamate receptors and can induce neuronal activity, potentially upregulating Calcyon expression.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$66.00
$325.00
$587.00
$1018.00
28
(1)

Retinoic acid regulates gene expression during neural development and may influence Calcyon expression in neuronal cells.

N-Methyl-D-Aspartic acid (NMDA)

6384-92-5sc-200458
sc-200458A
50 mg
250 mg
$109.00
$369.00
2
(1)

NMDA receptor activation by its agonist can modulate synaptic plasticity and may upregulate Calcyon expression.

Lithium

7439-93-2sc-252954
50 g
$214.00
(0)

Lithium is used in neuropsychiatric treatments and can affect signaling pathways, potentially influencing Calcyon expression.

Valproic Acid

99-66-1sc-213144
10 g
$87.00
9
(1)

Valproic acid affects neural plasticity and has been shown to affect the expression of various genes in the brain, possibly including Calcyon.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

5-Azacytidine is a DNA methylation inhibitor and could upregulate gene expression, potentially affecting Calcyon.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$31.00
$47.00
$84.00
$222.00
19
(3)

Sodium butyrate is a histone deacetylase inhibitor that can lead to chromatin remodeling and affect gene expression, including that of Calcyon.

Fluoxetine

54910-89-3sc-279166
500 mg
$318.00
9
(1)

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that may alter gene expression in the brain, potentially affecting Calcyon.