Calcyon Antibody (G-8): sc-271004

Calcyon Antibody (G-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects Calcyon protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Calcyon antibody (G-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Calcyon protein is a single transmembrane protein that plays a crucial role in modulating D1 dopamine receptors, which are the most prevalent dopamine receptors in the central nervous system. These receptors are essential for regulating synaptic transmission, influencing behaviors, and facilitating neuron growth and differentiation. Calcyon is predominantly located in neuronal cell bodies and processes of the cortex and hippocampus, with notable abundance in pyramidal neurons. The interaction between Calcyon and D1 receptors leads to the release of intracellular calcium, a vital signaling molecule that affects various cellular processes, including neurotransmitter release and neuronal excitability. Understanding the function and interactions of Calcyon is important for elucidating its role in neurophysiological processes and potential implications in neurological disorders.

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Calcyon Antibody (G-8) References:

1. Dopaminergic behaviors and signal transduction mediated through adenylate cyclase and phospholipase C pathways.  |  Undie, AS., et al. 2000. Neuropharmacology. 39: 75-87. PMID: 10665821
2. Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.  |  Lezcano, N., et al. 2000. Science. 287: 1660-4. PMID: 10698743
3. Calcyon mRNA expression in the frontal-striatal circuitry and its relationship to vesicular processes and ADHD.  |  Heijtz, RD., et al. 2007. Behav Brain Funct. 3: 33. PMID: 17623072
4. Calcyon is necessary for activity-dependent AMPA receptor internalization and LTD in CA1 neurons of hippocampus.  |  Davidson, HT., et al. 2009. Eur J Neurosci. 29: 42-54. PMID: 19120439
5. Calcyon upregulation in adolescence impairs response inhibition and working memory in adulthood.  |  Vazdarjanova, A., et al. 2011. Mol Psychiatry. 16: 672-84. PMID: 21403673
6. Cloning and expression of human and rat D1 dopamine receptors.  |  Zhou, QY., et al. 1990. Nature. 347: 76-80. PMID: 2168520
7. Calcyon stimulates neuregulin 1 maturation and signaling.  |  Yin, DM., et al. 2015. Mol Psychiatry. 20: 1251-60. PMID: 25349163
8. Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking.  |  Muthusamy, N., et al. 2015. J Neurochem. 132: 20-31. PMID: 25376768
9. Hevin-calcyon interaction promotes synaptic reorganization after brain injury.  |  Kim, JH., et al. 2021. Cell Death Differ. 28: 2571-2588. PMID: 33753902
10. D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus.  |  Huang, YY. and Kandel, ER. 1995. Proc Natl Acad Sci U S A. 92: 2446-50. PMID: 7708662
11. Molecular and chemical neuropharmacology of dopamine receptor subtypes.  |  Ogawa, N. 1995. Acta Med Okayama. 49: 1-11. PMID: 7762403
12. Differentiative effects of dopamine on striatal neurons involve stimulation of the cAMP/PKA pathway.  |  Schmidt, U., et al. 1998. Mol Cell Neurosci. 11: 9-18. PMID: 9608529

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Calcyon Antibody (G-8) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Calcyon Antibody (G-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Calcyon Antibody (G-8) Specifications

Alternate Product Name: Calcyon

Product Clone Name: G-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 4-178 deletion 134-151

Epitope Target: Calcyon

Epitope Species: human

Product Reactivity/Detection: Calcyon

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Calcyon Antibody (G-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin