Calcium Channel Modulators
Items 41 to 50 of 167 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Efonidipine hydrochloride | 111011-53-1 | sc-294464 sc-294464A | 10 mg 50 mg | $104.00 $416.00 | ||
Efonidipine hydrochloride acts as a calcium channel modulator by preferentially targeting both L-type and T-type calcium channels, promoting a dual mechanism of action. Its unique molecular architecture allows for selective binding, which modifies the gating properties of these channels. This compound demonstrates notable lipophilicity, enhancing membrane permeability. Additionally, its capacity to engage in electrostatic interactions can significantly influence channel dynamics and cellular calcium homeostasis. | ||||||
SN-6 | 415697-08-4 | sc-203698 sc-203698A | 10 mg 50 mg | $198.00 $825.00 | 2 | |
SN-6 functions as a calcium channel modulator by exhibiting a unique affinity for specific calcium channel subtypes, particularly influencing their conformational states. Its structural features facilitate distinct interactions with channel proteins, altering their activation thresholds. The compound's kinetic profile reveals rapid binding and unbinding rates, allowing for fine-tuning of calcium influx. Furthermore, its hydrophobic characteristics enhance its interaction with lipid bilayers, impacting channel accessibility and function. | ||||||
SB-366791 | 472981-92-3 | sc-222293 sc-222293A | 5 mg 25 mg | $64.00 $269.00 | 3 | |
SB-366791 acts as a calcium channel modulator by selectively targeting and stabilizing certain channel conformations, thereby influencing ion permeability. Its unique molecular architecture promotes specific interactions with the channel's voltage-sensing domains, leading to altered gating dynamics. The compound exhibits a notable ability to modulate channel kinetics, with a pronounced effect on inactivation rates. Additionally, its lipophilic nature enhances membrane penetration, further affecting channel behavior. | ||||||
Nitrendipine | 39562-70-4 | sc-201466 sc-201466A sc-201466B | 50 mg 100 mg 500 mg | $109.00 $160.00 $458.00 | 6 | |
Nitrendipine functions as a calcium channel modulator by engaging with the channel's alpha-1 subunit, promoting a distinct conformational state that alters ion flow. Its unique structure facilitates specific hydrogen bonding and hydrophobic interactions, enhancing selectivity for L-type calcium channels. This compound exhibits a remarkable influence on the activation threshold, effectively shifting the voltage-dependence of channel opening. Its dynamic interaction with lipid bilayers also contributes to its modulation efficacy. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin, free acid, acts as a calcium channel modulator by forming stable complexes with calcium ions, enhancing their transport across cellular membranes. Its unique ability to disrupt calcium homeostasis is attributed to its lipophilic nature, allowing it to integrate into lipid environments and alter membrane fluidity. This compound exhibits rapid kinetics in binding and releasing calcium, influencing intracellular signaling pathways and cellular responses to calcium fluctuations. | ||||||
CGP 37157 | 75450-34-9 | sc-202097 sc-202097A | 5 mg 25 mg | $115.00 $463.00 | 3 | |
CGP 37157 functions as a calcium channel modulator by selectively inhibiting mitochondrial calcium uptake, thereby influencing cellular energy metabolism. Its distinct interaction with the mitochondrial calcium uniporter alters calcium dynamics, leading to modified intracellular calcium signaling. The compound exhibits a unique binding affinity that stabilizes calcium in the cytosol, affecting various cellular processes and enhancing the understanding of calcium's role in cellular physiology. | ||||||
Manidipine dihydrochloride | 89226-75-5 | sc-205739 sc-205739A | 25 mg 100 mg | $75.00 $149.00 | ||
Manidipine dihydrochloride acts as a calcium channel modulator by selectively targeting L-type calcium channels, influencing vascular smooth muscle contraction. Its unique binding properties facilitate a reduction in calcium influx, which alters the dynamics of calcium-dependent signaling pathways. This modulation affects the kinetics of calcium release from the sarcoplasmic reticulum, providing insights into calcium homeostasis and its regulatory mechanisms in cellular environments. | ||||||
Pranidipine | 99522-79-9 | sc-212579 | 10 mg | $233.00 | ||
Pranidipine functions as a calcium channel modulator by engaging with L-type calcium channels, exhibiting a distinct affinity that alters channel conformation. This interaction leads to a decrease in calcium permeability, impacting intracellular calcium levels and influencing various signaling cascades. Its unique kinetic profile allows for a gradual modulation of calcium influx, which can affect the overall calcium balance within cells, shedding light on the intricate mechanisms of calcium regulation in physiological processes. | ||||||
Iberiotoxin | 129203-60-7 | sc-3585 sc-3585A | 10 µg 100 µg | $275.00 $500.00 | 16 | |
Iberiotoxin acts as a potent modulator of calcium channels, specifically targeting the ryanodine receptor subtype. By binding to these receptors, it induces conformational changes that enhance calcium release from the sarcoplasmic reticulum. This interaction results in a pronounced increase in intracellular calcium levels, influencing muscle contraction dynamics. Its unique binding kinetics and specificity provide insights into calcium signaling pathways, highlighting its role in cellular excitability and contractility. | ||||||
Verapamil Ethyl Methanethiosulfonate, Bromide | 353270-25-4 | sc-208483 | 5 mg | $297.00 | ||
Verapamil Ethyl Methanethiosulfonate, Bromide functions as a calcium channel modulator by selectively interacting with voltage-gated calcium channels. Its unique structure allows for the formation of covalent bonds with specific cysteine residues, altering channel conformation and gating dynamics. This modulation affects calcium influx, influencing various cellular processes. The compound's distinct reactivity and binding affinity contribute to its role in regulating calcium-dependent signaling pathways, showcasing its intricate molecular behavior. | ||||||