Molecular structure of Iberiotoxin, CAS Number: 129203-60-7
Iberiotoxin (CAS 129203-60-7)
See product citations (16)
Alternate Names:
IbTX; IBERIOTOXIN SCORPION BUTHUS TAMULUS
Application:
Iberiotoxin is a highly selective and potent high conductance Ca2+-activated K+ channel blocker
CAS Number:
129203-60-7
Purity:
≥98%
Molecular Weight:
4230.85
Molecular Formula:
C179H274N50O55S7
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Iberotoxin is a highly selective and potent blocker of the MaxiK (high conductance Ca2+ activated K+ channels) that does not affect other types of voltage-dependent K+ channels. Because of iberiotoxin′s strong ability to block Ca2+ activated K+ channels, in mammalian motor nerve terminals the compound can induce dihydropyridine sensitive release of ACh. In rat organotypic dorsal striatal slices iberiotoxin and margatoxin (sc-358754) were both observed to induce production of c-fos like mRNA and protein. Iberiotoxin is an inhibitor of MaxiKalpha.
Iberiotoxin (CAS 129203-60-7) References
- Electrostatic mutations in iberiotoxin as a unique tool for probing the electrostatic structure of the maxi-K channel outer vestibule. | Mullmann, TJ., et al. 1999. Biochemistry. 38: 2395-402. PMID: 10029533
- Margatoxin and iberiotoxin, two selective potassium channel inhibitors, induce c-fos like protein and mRNA in rat organotypic dorsal striatal slices. | Saria, A., et al. 2000. Amino Acids. 19: 23-31. PMID: 11026470
- Iberiotoxin-induced block of Ca2+-activated K+ channels induces dihydropyridine sensitivity of ACh release from mammalian motor nerve terminals. | Flink, MT. and Atchison, WD. 2003. J Pharmacol Exp Ther. 305: 646-52. PMID: 12606686
- Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: selectivity between voltage-gated and Maxi-K channels. | Gao, YD. and Garcia, ML. 2003. Proteins. 52: 146-54. PMID: 12833539
- Mode of action of iberiotoxin, a potent blocker of the large conductance Ca(2+)-activated K+ channel. | Candia, S., et al. 1992. Biophys J. 63: 583-90. PMID: 1384740
- Role for calcium-activated potassium channels (BK) in growth control of human malignant glioma cells. | Weaver, AK., et al. 2004. J Neurosci Res. 78: 224-34. PMID: 15378515
- Description and role in proliferation of iberiotoxin-sensitive currents in different human mammary epithelial normal and cancerous cells. | Roger, S., et al. 2004. Biochim Biophys Acta. 1667: 190-9. PMID: 15581855
- Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells. | Lam, FF., et al. 2006. Eur J Pharmacol. 546: 28-35. PMID: 16928370
- Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. | Galvez, A., et al. 1990. J Biol Chem. 265: 11083-90. PMID: 1694175
- Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. | Seto, SW., et al. 2007. Br J Pharmacol. 151: 987-97. PMID: 17558433
- Synthesis of an iberiotoxin derivative by chemical ligation: a method for improved yields of cysteine-rich scorpion toxin peptides. | Bingham, JP., et al. 2009. Peptides. 30: 1049-57. PMID: 19463736
- Iberiotoxin-sensitive and -insensitive BK currents in Purkinje neuron somata. | Benton, MD., et al. 2013. J Neurophysiol. 109: 2528-41. PMID: 23446695
- Iberiotoxin and clofilium regulate hyperactivation, acrosome reaction, and ion homeostasis synergistically during human sperm capacitation. | Wang, Y., et al. 2023. Mol Reprod Dev. 90: 129-140. PMID: 36682071
Inhibitor of:
CaMKIIN2, KCNMB2, KCNMB3, KCNT1, KCNT2, LRRC26, MaxiK, MaxiKβ, OR2T34, SK3, and TMEM17.Activator of:
AKAP 100, and KV2.2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Iberiotoxin, 10 µg | sc-3585 | 10 µg | $270.00 | |||
Iberiotoxin, 100 µg | sc-3585A | 100 µg | $490.00 |