SB-366791 CAS: 472981-92-3
MF: C16H14NO2Cl
MW: 287.74
A potent and selective vanilloid receptor (TRPV1) antagonist.

SB-366791 (CAS 472981-92-3)

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Alternate Names: N-(3-Methoxyphenyl)-4-chlorocinnamide
Application: SB-366791 is a potent and selective vanilloid receptor (TRPV1) antagonist
CAS Number: 472981-92-3
Molecular Weight: 287.74
Molecular Formula: C16H14NO2Cl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

SB-366791 is a selective and competitive VR1 (TRPV1) antagonist that is commonly used in pain research. The vanilloid recepter type 1 (VR1) is a non-selective cation channel gated by capsaicin, noxious heat, and protons. VR1 is present in primary sensory neurons and in both central and peripheral sensory nerve terminals.


References

1: M.J. Gunthorpe et al. Neuropharmacology 2004 46 133

Physical State :
Solid
Solubility :
Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml with warming).
Storage :
Store at room temperature
Melting Point :
165-167° C
Boiling Point :
494.25° C at 760 mmHg (Predicted)
Density :
1.27 g/cm3 (Predicted)
Refractive Index :
n20D 1.65 (Predicted)
IC50 :
Vanilloid receptor: IC50 = 18 nM (human)
pK Values :
pKa: 12.57 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
667594
MDL Number :
MFCD01033818
SMILES :
COC1=CC=CC(=C1)NC(=O)/C=C/C2=CC=C(C=C2)Cl

Download SDS (MSDS)

Certificate of Analysis

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