Molecular structure of SN-6, CAS Number: 415697-08-4
SN-6 (CAS 415697-08-4)
See product citations (2)
Alternate Names:
2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
Application:
SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor
CAS Number:
415697-08-4
Purity:
≥98%
Molecular Weight:
402.16
Molecular Formula:
C20H22N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
QUICK LINKS
Ordering Information
Product Citations
Description
Technical Information
Safety Information
SDS & Certificate of Analysis
SN-6 is a selective Na+/Ca2+exchange (NCX) inhibitor, displaying some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. SN-6 has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943. This compound acts as an anti-ischemic, potently protecting against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).
SN-6 (CAS 415697-08-4) References
- The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. | Iwamoto, T., et al. 2004. Mol Pharmacol. 66: 45-55. PMID: 15213295
- Forefront of Na+/Ca2+ exchanger studies: molecular pharmacology of Na+/Ca2+ exchange inhibitors. | Iwamoto, T. 2004. J Pharmacol Sci. 96: 27-32. PMID: 15359084
- [Characterization of SN-6, a novel exchange inhibitor and its renal protective effect]. | Inoue, Y., et al. 2004. Clin Calcium. 14: 84-91. PMID: 15577102
- YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. | Iwamoto, T. and Kita, S. 2006. Mol Pharmacol. 70: 2075-83. PMID: 16973719
- The Na+/Ca2+ exchanger inhibitor, KB-R7943, blocks a nonselective cation channel implicated in chemosensory transduction. | Pezier, A., et al. 2009. J Neurophysiol. 101: 1151-9. PMID: 19118110
- PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na⁺/Ca²⁺ exchanger in guinea pig airway smooth muscle. | Flores-Soto, E., et al. 2012. Eur J Pharmacol. 674: 439-44. PMID: 22119380
- Chronic nicotine exposure selectively activates a carrier-mediated release of endogenous glutamate and aspartate from rat hippocampal synaptosomes. | Marchi, M., et al. 2012. Neurochem Int. 60: 622-30. PMID: 22417725
- Reversed synaptic effects of hypocretin and NPY mediated by excitatory GABA-dependent synaptic activity in developing MCH neurons. | Li, Y., et al. 2013. J Neurophysiol. 109: 1571-8. PMID: 23255725
- Glutamate-induced ATP synthesis: relationship between plasma membrane Na+/Ca2+ exchanger and excitatory amino acid transporters in brain and heart cell models. | Magi, S., et al. 2013. Mol Pharmacol. 84: 603-14. PMID: 23913256
- The dual face of glutamate: from a neurotoxin to a potential survival factor-metabolic implications in health and disease. | Magi, S., et al. 2019. Cell Mol Life Sci. 76: 1473-1488. PMID: 30599069
- Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death. | Hu, HJ., et al. 2019. Br J Pharmacol. 176: 2691-2707. PMID: 31034096
Inhibitor of:
NCX1, NCX2, and NCX3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
SN-6, 10 mg | sc-203698 | 10 mg | $198.00 | |||
| US: Only available in the US | ||||||
SN-6, 50 mg | sc-203698A | 50 mg | $825.00 | |||
| US: Only available in the US | ||||||