SN-6 CAS: 415697-08-4
MF: C20H22N2O5S
SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor.

SN-6 (CAS 415697-08-4)

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Alternate Names: 2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylic acid ethyl ester
Application: SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor
CAS Number: 415697-08-4
Purity: ≥98%
Molecular Weight: 402.16
Molecular Formula: C20H22N2O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
* Refer to Certificate of Analysis for lot specific data (including water content).

SN-6 is a selective Na+/Ca2+exchange (NCX) inhibitor, displaying some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. SN-6 has some affinity for mACh receptors (IC50 = 18 μM) but minimal activity against NCKX2 and various receptors and ion channels (IC50 > 30 μM). Preferentially blocks Ca2+ influx mode and is more selective for NCX isoforms than KB-R7943. This compound acts as an anti-ischemic, potently protecting against hypoxia-induced renal tubular cell damage (IC50 = 0.63 μM).


References

1. Inoue, Y., Ito, K., Sakaue, T., Iwamoto, T. and Kita, S. 2004. Characterization of SN-6, a novel exchange inhibitor and its renal protective effect]. Clin Calcium. 14(8): 84-91. PMID: 15577102

2. Iwamoto, T. 2004. Forefront of Na+/Ca2+ exchanger studies: molecular pharmacology of Na+/Ca2+ exchange inhibitors. J. Pharmacol. Sci. 96(1): 27-32. PMID: 15359084

3. Iwamoto, T., Inoue, Y., Ito, K., Sakaue, T., Kita, S. and Katsuragi, T. 2004. The exchanger inhibitory peptide region-dependent inhibition of Na+/Ca2+ exchange by SN-6 [2-[4-(4-nitrobenzyloxy)benzyl]thiazolidine-4-carboxylic acid ethyl ester], a novel benzyloxyphenyl derivative. Mol. Pharmacol. 66(1): 45-55. PMID: 15213295

4. Iwamoto, T. and Kita, S. 2006. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibits NCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol. Pharmacol. 70(6): 2075-2083. PMID: 16973719

Physical State :
Solid
Solubility :
Soluble in DMSO (100 mM).
Storage :
Desiccate at 4° C
Melting Point :
222.14° C (Predicted)
Boiling Point :
~581.2° C at 760 mmHg (Predicted)
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.61 (Predicted)
IC50 :
Hypoxia-induced renal tubular cell damage: IC50 = 0.63 µM; Intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1: IC50 = 2.9 µM; Intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX3: IC50 = 8.6 µM; Intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX2: IC50 = 16 µM; mACh receptors : IC50 = 18 µM
pK Values :
pKb: 6.63 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
PubChem CID :
MDL Number :
MFCD06798326
SMILES :
CCOC(=O)C1CSC(N1)CC2=CC=C(C=C2)OCC3=CC=C(C=C3)[N+](=O)[O-]

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Certificate of Analysis

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SN-6 (CAS 415697-08-4)  Product Citations

See how others have used SN-6 (CAS 415697-08-4). Click on the entry to view the PubMed entry .

Citations 1 to 2 of 2 total

PMID: # 30892074  Amarelle, L. et al. 2019. Am. J. Physiol. Lung Cell Mol. Physiol. 316: L1094-L1106.

PMID: # 26418956  van der Hagen, EA.|van Loon, EP.|Verkaart, S.|Latta, F.|Bindels, RJ.|Hoenderop, JG.| et al. 2015. Nephron. 131: 145-52.

Citations 1 to 2 of 2 total
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