cadherin-24 Activators
Cadherin-24 activators function through a diverse array of biochemical mechanisms to enhance the protein's cell adhesion capability. Certain small molecules operate by increasing the intracellular concentration of secondary messengers such as cAMP, which influences cell signaling pathways that promote the translocation and stabilization of cadherin-24 at the plasma membrane, thus improving its adhesive function. Others work by altering the phosphorylation status of the protein, either through the activation of kinases or by inhibiting the action of phosphatases, thereby maintaining cadherin-24 in a functionally active state. Additionally, some compounds indirectly increase the stability and function of cadherin-24 by modulating calcium signaling, which is integral to cadherin function. This can be achieved by either disrupting calcium homeostasis or by acting as agonists to calcium channels, leading to enhanced intracellular calcium levels that are vital for cadherin-24 mediated cell-cell adhesion.
Another subset of cadherin-24 activators affects the protein's function by influencing the epigenetic landscape or cellular signaling pathways that impact the protein. For instance, inhibition of enzymes that modify chromatin structure can result in increased expression of cadherin-24, contributing to its adhesive activity. Additionally, some molecules may enhance the interaction between cadherin-24 and its binding partners within the cell, such as β-catenin, which is crucial for the anchoring of cadherin-24 to the cytoskeleton and the strengthening of cell adhesion.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Activates adenylate cyclase, increasing cAMP levels. Elevated cAMP enhances the junctional stability of cadherin-24 by promoting its translocation to the plasma membrane and increasing its adhesive function. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $30.00 | ||
Serves as a cofactor that is crucial for the proper function of kinases which phosphorylate cadherin-24, thereby stabilizing its presence at the cell surface and enhancing cell adhesion. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3β leading to the stabilization of β-catenin. Stabilized β-catenin can then bind to cadherin-24 and enhance its cell adhesion function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Activates Protein Kinase C (PKC) which can phosphorylate cadherin-24, promoting its cell surface expression and adhesion activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000B sc-24000C | 10 µg 100 µg 500 µg 1 mg | $160.00 $750.00 $1400.00 $3000.00 | 59 | |
Inhibits protein phosphatases, leading to increased phosphorylation status of cellular proteins. This can enhance the stability and adhesive function of cadherin-24 by maintaining its phosphorylated state. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Inhibits histone deacetylases (HDACs), which can result in a more accessible chromatin structure at the cadherin-24 locus, indirectly enhancing its expression and thus its cell adhesion activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Increases intracellular calcium concentration, which is required for the proper functioning of cadherins including cadherin-24, thereby enhancing its adhesive properties. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
Inhibits calmodulin, which can impact calcium signaling, indirectly increasing the stability and function of cadherin-24 in cell adhesion. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Disrupts calcium homeostasis, indirectly enhancing the function of calcium-dependent proteins such as cadherin-24, thereby increasing its cell adhesion capability. | ||||||
(±)-Bay K 8644 | 71145-03-4 | sc-203324 sc-203324A sc-203324B | 1 mg 5 mg 50 mg | $82.00 $192.00 $801.00 | ||
Acts as an L-type calcium channel agonist, increasing intracellular calcium that is essential for cadherin-24 mediated adhesion. | ||||||