Cables1 Activators
Cables1, short for Cdk5 and Abl enzyme substrate 1, belongs to a distinct chemical class known as Cables1 Activators. This class is characterized by its ability to modulate the activity of Cdk5 and Abl enzymes, crucial players in cellular processes. Cables1, a cytoplasmic protein, serves as a substrate for both cyclin-dependent kinase 5 (Cdk5) and Abelson tyrosine kinase (Abl), regulating cellular functions such as cytoskeletal dynamics, neuronal migration, and cell cycle progression. The activators within this chemical class finely tune the phosphorylation state of Cables1, thereby influencing downstream signaling pathways and cellular events.
At the molecular level, Cables1 Activators interact with specific binding sites on Cables1, promoting conformational changes that enhance its susceptibility to phosphorylation by Cdk5 and Abl enzymes. This intricate modulation of Cables1 activity highlights the nuanced regulatory mechanisms at play within cellular signaling cascades. The activation of Cables1 by this chemical class underscores its importance as a regulatory node in various cellular processes, providing researchers with valuable insights into the intricate web of molecular interactions that govern fundamental biological functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
By inhibiting cyclin-dependent kinases, including Cdk2, this compound can potentially boost Cables1's role, given the interaction of Cables1 and Cdk2. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
As a cyclin-dependent kinase inhibitor targeting Cdk2 among others, it may enhance the function of Cables1 indirectly via its impact on Cdk2, a known interacting partner of Cables1. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
As a specific inhibitor of the Abl tyrosine kinases, Imatinib might indirectly amplify the function of Cables1 by controlling the activity of Abl kinase, an interacting partner of Cables1. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
By inhibiting a broad range of targets including Abl kinases, Dasatinib might indirectly stimulate Cables1's function via its impact on Abl kinases, which are known to interact with Cables1. | ||||||
Nilotinib | 641571-10-0 | sc-202245 sc-202245A | 10 mg 25 mg | $205.00 $405.00 | 9 | |
As a potent Abl tyrosine kinase inhibitor, Nilotinib could indirectly promote Cables1 activity by controlling the function of Abl kinases, with which Cables1 interacts. | ||||||
Purvalanol A | 212844-53-6 | sc-224244 sc-224244A | 1 mg 5 mg | $71.00 $291.00 | 4 | |
As a potent inhibitor of cyclin-dependent kinases, including Cdk2, Purvalanol A may enhance the role of Cables1 indirectly via its impact on Cdk2, which interacts with Cables1. | ||||||
SU 9516 | 377090-84-1 | sc-222330 sc-222330A | 5 mg 25 mg | $122.00 $383.00 | 3 | |
As a selective Cdk2 inhibitor, SU9516 might stimulate Cables1 function indirectly via its inhibitory impact on Cdk2, a known interacting partner of Cables1. | ||||||
Olomoucine | 101622-51-9 | sc-3509 sc-3509A | 5 mg 25 mg | $72.00 $274.00 | 12 | |
As an inhibitor of cyclin-dependent kinases, including Cdk2, Olomoucine might indirectly boost Cables1 action via its control over Cdk2, which interacts with Cables1. | ||||||
Indirubin-3′-monoxime | 160807-49-8 | sc-202660 sc-202660A sc-202660B | 1 mg 5 mg 50 mg | $77.00 $315.00 $658.00 | 1 | |
As a cyclin-dependent kinase inhibitor that primarily targets Cdk2, Indirubin-3'-monoxime may indirectly stimulate Cables1 via its control over Cdk2, a protein that Cables1 is known to interact with. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $67.00 $306.00 | 2 | |
As a potent inhibitor of Cdk1, Cdk2, and GSK-3 beta, Alsterpaullone could potentially boost Cables1 function indirectly through its effect on Cdk2. | ||||||