Cables1 Antibody (D-10): sc-374316
- Cables1 Antibody (D-10) is a mouse monoclonal IgG2a κ Cables1 antibody provided at 200 µg/ml
- raised against amino acids 1-280 mapping at the N-terminus of Cables1 of mouse origin
- Cables1 Antibody (D-10) is recommended for detection of Cables1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Cables1 Antibody (D-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Cables1 Antibody (D-10) for WB and IHC(P) applications. These reagents are now offered in bundles with Cables1 Antibody (D-10) (see ordering information below).
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Cables1 Antibody (D-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects Cables1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Cables1 (D-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cables1, consisting of 568 amino acids, plays a crucial role in linking the Abelson (Abl) tyrosine kinase to cyclin-dependent kinase 5 (Cdk5), which is essential for neuronal signaling and development. The interaction between Cables1 and Cdk5 is particularly important as Cables1 acts as a substrate for phosphorylation by the Cdk5/p35 kinase, thereby regulating Cdk5 activity and localization within the neuron. Additionally, Cables1 contains six potential SH3 binding motifs clustered at its amino-terminus, which facilitate interaction with Abl, forming a trimolecular complex that co-localizes in cortical axons, especially in growth cones. This complex functions as an adaptor or scaffolding mechanism, ensuring proper signaling pathways are activated during neuronal development and maintenance. Understanding Cables1 dynamics and interactions is vital, as disruptions in these pathways can lead to neurodevelopmental disorders and other neurological conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cables1 Antibody (D-10) References:
- Cycling, stressed-out and nervous: cellular functions of c-Abl. | Van Etten, RA. 1999. Trends Cell Biol. 9: 179-86. PMID: 10322452
- The kinase-deficient Src acts as a suppressor of the Abl kinase for Cbl phosphorylation. | Shishido, T., et al. 2000. Proc Natl Acad Sci U S A. 97: 6439-44. PMID: 10829062
- More cables to Abl. | Cowan, CA. and Henkemeyer, M. 2000. Neuron. 26: 543-4. PMID: 10896146
- Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. | Zukerberg, LR., et al. 2000. Neuron. 26: 633-46. PMID: 10896159
- Identification and characterization of two novel SH2 domain-containing proteins from a yeast two hybrid screen with the ABL tyrosine kinase. | Oda, T., et al. 1997. Oncogene. 15: 1255-62. PMID: 9315092
- Engineering the substrate specificity of the Abl tyrosine kinase. | Till, JH., et al. 1999. J Biol Chem. 274: 4995-5003. PMID: 9988744
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cables1 Antibody (D-10) | sc-374316 | 200 µg/ml | $316.00 | |||
Cables1 Antibody (D-10): m-IgGκ BP-HRP Bundle | sc-522698 | 200 µg Ab, 40 µg BP | $354.00 | |||
Cables1 Antibody (D-10): m-IgG2a BP-HRP Bundle | sc-546121 | 200 µg Ab; 10 µg BP | $354.00 | |||
Cables1 Antibody (D-10) AC | sc-374316 AC | 500 µg/ml, 25% agarose | $416.00 | |||
Cables1 Antibody (D-10) HRP | sc-374316 HRP | 200 µg/ml | $316.00 | |||
Cables1 Antibody (D-10) FITC | sc-374316 FITC | 200 µg/ml | $330.00 | |||
Cables1 Antibody (D-10) PE | sc-374316 PE | 200 µg/ml | $343.00 | |||
Cables1 Antibody (D-10) Alexa Fluor® 488 | sc-374316 AF488 | 200 µg/ml | $357.00 | |||
Cables1 Antibody (D-10) Alexa Fluor® 546 | sc-374316 AF546 | 200 µg/ml | $357.00 | |||
Cables1 Antibody (D-10) Alexa Fluor® 594 | sc-374316 AF594 | 200 µg/ml | $357.00 | |||
Cables1 Antibody (D-10) Alexa Fluor® 647 | sc-374316 AF647 | 200 µg/ml | $357.00 | |||
Cables1 Antibody (D-10) Alexa Fluor® 680 | sc-374316 AF680 | 200 µg/ml | $357.00 | |||
Cables1 Antibody (D-10) Alexa Fluor® 790 | sc-374316 AF790 | 200 µg/ml | $357.00 |