C8orf47 Activators
C8orf47 Activators operate through a variety of mechanisms, affecting different signaling pathways and cellular processes to potentially enhance the functional activity of C8orf47. Compounds such as Forskolin and IBMX increase intracellular levels of cAMP, a pivotal second messenger in cellular signaling. The elevated cAMP activates PKA, which can phosphorylate a broad range of target proteins. If C8orf47 is regulated by PKA or is part of a PKA-dependent pathway, these compounds can enhance its functional activity. Similarly, dibutyryl-cAMP, by mimicking cAMP, can engage the same PKA-dependent pathways to activate proteins associated with C8orf47.
LY294002 and U0126 are kinase inhibitors that target PI3K and MEK, respectively. While their primary action is inhibitory, the complex feedback mechanisms in cellular signaling networks can lead to unexpected outcomes, such as the upregulation of alternative pathways that could enhance the activity of C8orf47.Okadaic acid, by inhibiting protein phosphatases, can lead to a net increase in protein phosphorylation, potentially affecting C8orf47 activity if it is regulated by dephosphorylation events. Retinoic acid, as a transcriptional modulator, could impact the expression of genes related to C8orf47 or its regulatory proteins, thereby influencing its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP and cGMP. By inhibiting phosphodiesterases, IBMX can raise intracellular levels of cAMP and cGMP, which in turn can activate PKA or PKG and subsequently enhance the activity of C8orf47 if it is regulated by these kinases. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), which is involved in various signaling pathways. PKC activation can lead to the phosphorylation of target proteins that may interact with or regulate C8orf47, thus enhancing its functional activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calmodulin-dependent kinase (CaMK), which may phosphorylate proteins related to C8orf47's function or regulatory pathways, thereby enhancing C8orf47's activity. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin interacts with the insulin receptor, triggering a signaling cascade that includes the PI3K/Akt pathway. Activation of this pathway can lead to downstream effects that may enhance the activity of C8orf47 if it is influenced by the insulin signaling pathway. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases can result in increased phosphorylation levels of various proteins, which might enhance the functional activity of C8orf47, assuming it is regulated by phosphorylation status. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression by activating nuclear receptors. If C8orf47 is involved in a pathway regulated by retinoic acid, its functional activity could be enhanced through altered gene expression patterns. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to an increase in cytosolic calcium levels. This increase in calcium can activate calcium-dependent signaling pathways, potentially enhancing C8orf47 activity if it is calcium-regulated. | ||||||
Calcium dibutyryladenosine cyclophosphate | 362-74-3 | sc-482205 | 25 mg | $147.00 | ||
Dibutyryl-cAMP is a cell-permeable analog of cAMP that can activateGiven the lack of direct information on the specific pathways or biological processes involving C8orf47, the following are logical choices of chemical compounds that could influence pathways potentially related to the activation of C8orf47. These compounds have been selected based on their known effects on cellular signaling pathways that could indirectly lead to the functional activation of C8orf47. | ||||||