C8α Activators
C8α Activators represent a diverse class of compounds that can enhance the function of C8α by activating the complement system, which leads to the formation of the MAC. These chemical compounds act on various pathways to trigger complement activation, either through the classical, lectin, or alternative pathways. For instance, Zymosan A, Lipopolysaccharides, and Concanavalin A are known activators of these pathways and by extension, can enhance the functional activity of C8α.
In addition, some compounds, like Methyl-β-cyclodextrin, influence the formation of MAC by disrupting lipid rafts, thereby indirectly enhancing the functional activity of C8α. Similarly, compounds like Leucine-enkephalin, Spermine, Piceatannol, and Capsaicin enhance various cellular functions such as phagocytosis and the production of superoxide anions, which may indirectly increase the functional activity of C8α. Therefore, the diverse mechanisms of these chemical compounds converge on the enhancement of C8α's function, primarily through the activation of the complement system, leading to an increased efficiency of the MAC.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
LPS is an endotoxin that can trigger the activation of the complement system through the alternative pathway, which might enhance the functional activity of C8α. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
Concanavalin A is a plant lectin that binds to specific glycoproteins on cell surfaces and can activate the lectin pathway of the complement system, potentially increasing C8α activity. | ||||||
Leu-Enkephalin | 58822-25-6 | sc-394447 | 25 mg | $219.00 | ||
Leucine-enkephalin is an endogenous opioid peptide that enhances phagocytosis and the production of superoxide anions, which might indirectly enhance the functional activity of C8α. | ||||||
Spermine | 71-44-3 | sc-212953A sc-212953 sc-212953B sc-212953C | 1 g 5 g 25 g 100 g | $61.00 $196.00 $277.00 $901.00 | 1 | |
Spermine is a polyamine compound that has been shown to enhance the alternative pathway of the complement system, which could increase C8α activity. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Polyinosinic acid is a polynucleotide that activates the classical complement pathway, potentially enhancing C8α activity. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $95.00 $263.00 $529.00 | ||
Poly-L-lysine is a polypeptide that can activate the classical pathway of the complement system, potentially enhancing C8α activity. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
Methyl-β-cyclodextrin is a cholesterol-depleting agent that can disrupt lipid rafts and potentially enhance MAC formation, thus indirectly enhancing C8α activity. | ||||||
Piceatannol | 10083-24-6 | sc-200610 sc-200610A sc-200610B | 1 mg 5 mg 25 mg | $51.00 $71.00 $199.00 | 11 | |
Piceatannol is a hydroxylated analog of resveratrol that has been shown to enhance the phagocytic activity of neutrophils, which could indirectly enhance the functional activity of C8α. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin is a chili pepper extract that has been shown to enhance the phagocytic activity of macrophages, which could indirectly enhance the functional activity of C8α. | ||||||