C4orf14 Inhibitors
Nitric Oxide Associated 1, known by its gene name "NOA1" or "nitric oxide associated protein 1," is a mitochondrial protein that plays a crucial role in the regulation of mitochondrial function and biogenesis. NOA1 is involved in the production of nitric oxide (NO) within the mitochondria, a molecule that serves as an important cellular signaling component. NO is known for its diverse effects in various biological processes, including vasodilation, neurotransmission, and immune response.In the context of mitochondria, NOA1 is implicated in the fine-tuning of mitochondrial respiration, as NO can reversibly inhibit cytochrome c oxidase (Complex IV) in the electron transport chain. This interaction is part of the mechanism by which cells modulate oxidative phosphorylation efficiency and control reactive oxygen species (ROS) production. By influencing the mitochondrial respiratory rate, NOA1 indirectly affects the production of ATP, the cell's energy currency, and thus plays a role in energy homeostasis.
Additionally, NOA1 is associated with mitochondrial quality control. It may participate in the regulation of mitochondrial dynamics, including processes like fission and fusion, as well as mitophagy, the selective degradation of damaged or superfluous mitochondria. These activities are vital for maintaining a healthy population of mitochondria within the cell, which is essential for cellular health and function.Given its involvement in mitochondrial regulation, NOA1 has been of interest in research related to aging and metabolic diseases, as well as in conditions characterized by mitochondrial dysfunction, such as neurodegenerative diseases. Alterations in NOA1 expression or function can lead to disrupted cellular metabolism and have been linked to various pathophysiological conditions, emphasizing the importance of NOA1 in cellular physiology and homeostasis.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $48.00 $107.00 $328.00 | 45 | |
A non-selective inhibitor of nitric oxide synthase (NOS), L-NAME can reduce NO production, potentially influencing NOA1-related pathways by altering NO availability. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
An inhibitor of guanylate cyclase, Methylene Blue can decrease NO-mediated effects, potentially affecting processes regulated by NOA1 through modulation of NO signaling. | ||||||
7-Nitroindazole | 2942-42-9 | sc-3569 | 100 mg | $70.00 | 4 | |
A selective inhibitor of neuronal NOS (nNOS), 7-NI can specifically reduce NO production in neurons, indirectly influencing NOA1's role in cellular energy metabolism and NO synthesis. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
An inhibitor of mitochondrial complex I, Rotenone can impact cellular energy metabolism, potentially affecting NOA1's function in mitochondria. | ||||||
Antimycin A | 1397-94-0 | sc-202467 sc-202467A sc-202467B sc-202467C | 5 mg 10 mg 1 g 3 g | $55.00 $63.00 $1675.00 $4692.00 | 51 | |
An inhibitor of mitochondrial complex III, Antimycin A affects cellular respiration and could indirectly influence NOA1 by impacting mitochondrial function. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
A xanthine oxidase inhibitor, Allopurinol can reduce reactive oxygen species (ROS) production, indirectly affecting NOA1 by modulating oxidative stress and mitochondrial function. | ||||||
Mdivi-1 | 338967-87-6 | sc-215291 sc-215291B sc-215291A sc-215291C | 5 mg 10 mg 25 mg 50 mg | $67.00 $126.00 $251.00 $465.00 | 13 | |
A selective inhibitor of mitochondrial fission, mdivi-1 can influence mitochondrial dynamics, potentially affecting NOA1's role in mitochondrial function and energy metabolism. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenolic compound known to enhance mitochondrial function and induce NO production, Resveratrol might indirectly modulate NOA1 activity through its effects on mitochondria. | ||||||
Sodium nitroprusside dihydrate | 13755-38-9 | sc-203395 sc-203395A sc-203395B | 1 g 5 g 100 g | $43.00 $85.00 $158.00 | 7 | |
A donor of nitric oxide, Sodium Nitroprusside can modulate NO levels and signaling pathways, potentially affecting the cellular context in which NOA1 operates. | ||||||