Molecular structure of 7-Nitroindazole, CAS Number: 2942-42-9
7-Nitroindazole (CAS 2942-42-9)
See product citations (4)
Alternate Names:
7-NI
Application:
7-Nitroindazole is a specific inhibitor of neural nitric oxide synthase (nNOS)
CAS Number:
2942-42-9
Purity:
≥97%
Molecular Weight:
163.13
Molecular Formula:
C7H5N3O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
7-nitroindazole is a specific inhibitor of NOS1 (nNOS). Nitric oxide is a key player in the hippocampal long-term potentiation (LTP).
7-Nitroindazole (CAS 2942-42-9) References
- 7-nitroindazole differentially affects the anticonvulsant activity of antiepileptic drugs against amygdala-kindled seizures in rats. | Borowicz, KK., et al. 2000. Epilepsia. 41: 1112-8. PMID: 10999550
- 7-Nitroindazole, a nitric oxide synthase inhibitor, enhances the anticonvulsive action of ethosuximide and clonazepam against pentylenetetrazol-induced convulsions. | Borowicz, KK., et al. 2000. J Neural Transm (Vienna). 107: 1117-26. PMID: 11129101
- 7-nitroindazole, but not L-NAME or aminoguanidine, attenuates anaphylactic hypotension in conscious rats. | Zhang, W., et al. 2009. Shock. 31: 201-6. PMID: 18497703
- Effects of nitric oxide synthase inhibitors 1-(2-trifluoromethylphenyl)--imidazole (TRIM) and 7-nitroindazole (7-NI) on learning and memory in mice. | Mutlu, O., et al. 2011. Fundam Clin Pharmacol. 25: 368-77. PMID: 20608991
- 7-Nitroindazole blocks the prepulse inhibition disruption and c-Fos increase induced by methylphenidate. | Issy, AC. and Del Bel, EA. 2014. Behav Brain Res. 262: 74-83. PMID: 24406716
- 7-Nitroindazole enhances c-Fos expression in spinal neurons in rats realizing operant movements. | Man'kovskaya, YP., et al. 2014. Acta Histochem. 116: 1427-33. PMID: 25306252
- 7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate. | Herrero, MT., et al. 2023. Open Biol. 13: 220370. PMID: 37192671
- Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice. | Schulz, JB., et al. 1995. J Neurochem. 64: 936-9. PMID: 7530297
- Inhibition of neuronal nitric oxide synthase by 7-nitroindazole: effects upon local cerebral blood flow and glucose use in the rat. | Kelly, PA., et al. 1995. J Cereb Blood Flow Metab. 15: 766-73. PMID: 7545690
- The neuronal nitric oxide synthase inhibitor, 7-nitroindazole, protects against methamphetamine-induced neurotoxicity in vivo. | Itzhak, Y. and Ali, SF. 1996. J Neurochem. 67: 1770-3. PMID: 8858965
Inhibitor of:
AtNOS1, C4orf14, NOS1, and NOSIP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
7-Nitroindazole, 100 mg | sc-3569 | 100 mg | $70.00 |