Date published: 2025-12-10

1-800-457-3801

SCBT Portrait Logo
Seach Input

C3G Inhibitors

C3G inhibitors are a class of chemical compounds designed to target and modulate the activity of a specific protein known as C3G (Rap guanine nucleotide exchange factor 1 or RAPGEF1). C3G is a crucial signaling molecule involved in various cellular processes, particularly those related to cell growth, differentiation, and cytoskeletal organization. These inhibitors are designed to interfere with the normal function of C3G, either by blocking its activity or by altering its interaction with other cellular components. The primary goal of C3G inhibitors is to gain a better understanding of the role played by C3G in cellular signaling pathways. By inhibiting its function, researchers can elucidate the downstream effects and consequences of C3G modulation, thereby shedding light on its physiological and pathological roles. This class of inhibitors typically consists of small molecules or chemical compounds that have been specifically designed and synthesized to target C3G. Researchers use these inhibitors in laboratory settings to investigate the cellular responses and consequences of C3G inhibition, which can provide valuable insights into the molecular mechanisms underlying various cellular processes.

Items 1 to 10 of 12 total

Display:

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Wortmannin

19545-26-7sc-3505
sc-3505A
sc-3505B
1 mg
5 mg
20 mg
$66.00
$219.00
$417.00
97
(3)

Wortmannin is a metabolite that inhibits phosphoinositide 3-kinases (PI3K), which may indirectly downregulate C3G expression due to PI3K's role in signaling pathways that influence gene expression.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a synthetic molecule that selectively inhibits PI3K, thereby potentially reducing C3G expression through the inhibition of the PI3K/Akt pathway, which is often involved in the transcriptional regulation of various genes.

Rapamycin

53123-88-9sc-3504
sc-3504A
sc-3504B
1 mg
5 mg
25 mg
$62.00
$155.00
$320.00
233
(4)

Rapamycin is a macrolide compound that can inhibit mTOR, a key kinase that may regulate C3G expression indirectly by influencing protein synthesis and cellular growth signals.

Triciribine

35943-35-2sc-200661
sc-200661A
1 mg
5 mg
$102.00
$138.00
14
(1)

Triciribine specifically targets Akt, a kinase downstream of PI3K, and its inhibition can lead to reduced signaling through pathways that typically enhance C3G expression.

PD 98059

167869-21-8sc-3532
sc-3532A
1 mg
5 mg
$39.00
$90.00
212
(2)

PD98059 is an inhibitor of MEK, which acts upstream of ERK in the MAPK signaling pathway. Inhibition of this pathway can lead to decreased activation of transcription factors that regulate C3G expression.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 is another MEK inhibitor that can lead to reduced ERK signaling, potentially decreasing transcriptional activation of genes, including C3G.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

SB203580 is a selective inhibitor of p38 MAPK, which could modulate inflammatory response and stress-related pathways that might impact C3G expression indirectly.

SP600125

129-56-6sc-200635
sc-200635A
10 mg
50 mg
$40.00
$150.00
257
(3)

SP600125 is an inhibitor of JNK, and by modulating JNK activity, it could affect transcription factors and signaling pathways that regulate the expression of C3G.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Curcumin, a natural phenolic compound, may exert its effect by modulating various signaling pathways, including those that regulate gene expression, potentially affecting C3G levels.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

Resveratrol is a natural compound that can modulate sirtuin activity and influence signaling pathways related to longevity and stress response, possibly affecting C3G expression.