C330027C09Rik Activators
Cip2a, or the Cellular Inhibitor of Protein Phosphatase 2A, emerges as a pivotal player in the intricate orchestration of cellular processes, specifically in the realm of cell proliferation. Functionally, Cip2a is predicted to enable protein homodimerization activity, a characteristic that positions it as a key regulator in the delicate balance of cellular activities. Acting as an inhibitor of Protein Phosphatase 2A (PP2A), Cip2a exerts its influence upstream or within positive regulation of neural precursor cell proliferation and spermatogenesis. The cellular localization of Cip2a in the cytosol and plasma membrane underscores its involvement in fundamental cellular activities, with expression observed in vital regions such as the brain subventricular zone, hindlimb interdigital region, skin, and telencephalon. Importantly, the human ortholog, CIP2A, shares analogous functions, emphasizing the evolutionary conservation of its role across species.
The activation of Cip2a is a multifaceted process that intricately integrates with various signaling pathways and cellular mechanisms. While direct activators remain elusive, several chemicals indirectly modulate Cip2a activity by influencing key cellular processes. Retinoic Acid, for instance, impacts the RA signaling pathway, leading to altered gene expression and, consequently, influencing Cip2a regulation. Forskolin elevates intracellular cAMP levels, activating PKA and suggesting a potential cascade effect on Cip2a through post-translational modifications or gene expression changes. Calyculin A disrupts the phosphatase balance by inhibiting PP1 and PP2A, possibly favoring Cip2a phosphorylation and activation. Hesperidin and SB203580, through modulation of MAPK/ERK and p38 MAPK pathways, respectively, imply a broader network where Cip2a is indirectly regulated. Other chemicals, such as Wortmannin, SP600125, Genistein, Trichostatin A, PMA, LY294002, and 8-CPT-cAMP, collectively contribute to the intricate web of signaling events that indirectly impact Cip2a function. This multifaceted approach to Cip2a activation sheds light on the nuanced and interconnected nature of cellular regulation, where diverse pathways converge to finely tune the balance of cellular processes, particularly in the context of proliferation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid influences the RA signaling pathway, regulating Cip2a indirectly. Retinoic Acid activates RAR/RXR receptors, leading to altered gene expression. This modulates cellular processes impacting Cip2a regulation. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A sc-24000C | 10 µg 100 µg 1 mg | $160.00 $750.00 $3000.00 | 59 | |
Calyculin A, a protein phosphatase inhibitor, indirectly activates Cip2a. By inhibiting PP1 and PP2A, Calyculin A disrupts the phosphatase balance, potentially favoring Cip2a phosphorylation and activation. The altered phosphorylation state may enhance Cip2a function in cell proliferation regulation. | ||||||
Hesperidin | 520-26-3 | sc-205711 sc-205711A | 25 g 100 g | $80.00 $200.00 | 5 | |
Hesperidin, a flavonoid, modulates cellular processes that indirectly impact Cip2a. It is proposed to affect MAPK/ERK signaling, potentially influencing Cip2a through altered gene expression or post-translational modifications. This indirect activation pathway suggests a link between Hesperidin-mediated signaling and Cip2a regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAPK inhibitor, indirectly influences Cip2a. By inhibiting p38 MAPK, it may alter downstream signaling cascades, affecting gene expression or protein interactions that contribute to Cip2a activation. The intricate crosstalk between p38 MAPK and Cip2a suggests a potential indirect regulatory mechanism. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a PI3K inhibitor, indirectly modulates Cip2a activity. Inhibiting PI3K disrupts downstream signaling, potentially impacting Akt/mTOR pathways. This indirect influence on Cip2a suggests a connection between PI3K-mediated signaling and the regulation of Cip2a in cell proliferation processes. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, indirectly influences Cip2a through the JNK signaling pathway. Inhibiting JNK may alter downstream targets, impacting gene expression or post-translational modifications that regulate Cip2a function. The proposed indirect activation pathway highlights the intricate network of signaling events modulating Cip2a activity. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, a tyrosine kinase inhibitor, indirectly affects Cip2a. By inhibiting tyrosine kinases, it may impact downstream signaling cascades, potentially modulating gene expression or post-translational modifications associated with Cip2a regulation. This proposed indirect activation pathway suggests a link between tyrosine kinase signaling and Cip2a function. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A, a histone deacetylase inhibitor, indirectly influences Cip2a through epigenetic modifications. By inhibiting HDACs, it may alter chromatin structure, affecting gene expression associated with Cip2a regulation. This proposed indirect activation pathway highlights the potential role of epigenetic mechanisms in modulating Cip2a function. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA, a PKC activator, indirectly influences Cip2a through PKC-mediated signaling. Activated PKC may modulate downstream pathways, impacting gene expression or post-translational modifications associated with Cip2a regulation. This proposed indirect activation pathway suggests a link between PKC signaling and the intricate regulation of Cip2a. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002, a PI3K/Akt inhibitor, indirectly modulates Cip2a. Inhibiting PI3K/Akt disrupts downstream signaling, potentially impacting pathways associated with Cip2a regulation. This proposed indirect activation pathway highlights the intricate crosstalk between PI3K/Akt signaling and the regulation of Cip2a in cell proliferation processes. | ||||||