C20orf19 Inhibitors
Kizuna centrosomal protein, also known as C14orf166 or human chromosome 14 open reading frame 166, is a protein that plays a critical role in maintaining centrosome cohesion and function during mitosis. The term "kizuna" comes from Japanese, meaning "bonds" or "connections," aptly describing the protein's function in linking centrosome components.In the intricate process of cell division, the centrosome is a key organelle that serves as the main microtubule organizing center, orchestrating the formation of the spindle apparatus responsible for segregating chromosomes into daughter cells. Kizuna centrosomal protein ensures the integrity of the centrosomes and is particularly important during the G2 phase and mitosis when centrosomes duplicate and mature, enabling them to form bipolar spindles.
Molecularly, kizuna is associated with the PCM (pericentriolar material) and has been shown to interact with other centrosomal proteins, which are essential for spindle formation and stability. It is believed that kizuna contributes to the recruitment or anchoring of these proteins and microtubules to the centrosome, thus facilitating proper spindle assembly.Mutations or dysregulation of kizuna centrosomal protein can lead to errors in chromosome segregation and are implicated in the development of aneuploidy, a condition where cells have an abnormal number of chromosomes, which is a hallmark of many cancers. Investigating the precise mechanisms by which kizuna operates could provide insight into the fundamental processes of cell division and reveal potential targets for cancer therapy.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, indirectly affecting centrosome function and potentially influencing processes associated with Kizuna Centrosomal Protein. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
By stabilizing microtubules, Paclitaxel can impact centrosome dynamics, potentially affecting the function of KIZ in centrosome cohesion and spindle formation. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin interferes with microtubule function, which could indirectly impact KIZ function by affecting microtubule dynamics and centrosome-related processes. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds to tubulin and inhibits its polymerization, potentially influencing centrosome dynamics and indirectly affecting Kizuna Centrosomal Protein's role in cells. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
A cyclin-dependent kinase inhibitor, Roscovitine, may affect cell cycle progression and thus indirectly influence centrosomal dynamics and KIZ function. | ||||||
Purvalanol B | 212844-54-7 | sc-361300 sc-361300A | 10 mg 50 mg | $199.00 $846.00 | ||
As an inhibitor of cyclin-dependent kinases, Purvalanol A can alter cell cycle control, potentially impacting centrosome function and KIZ activity indirectly. | ||||||
Monastrol | 254753-54-3 | sc-202710 sc-202710A | 1 mg 5 mg | $120.00 $233.00 | 10 | |
Monastrol specifically inhibits kinesin Eg5, affecting spindle dynamics. This could indirectly influence KIZ activity by altering the mechanical forces acting on centrosomes. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $150.00 $1050.00 $1665.00 $3329.00 $4382.00 | 1 | |
A Plk1 inhibitor, BI 2536 can impact centrosome maturation and spindle assembly, potentially affecting KIZ-related processes in centrosome cohesion and function. | ||||||
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
As an Aurora kinase inhibitor, ZM447439 can disrupt spindle assembly and checkpoint function, possibly affecting KIZ function in centrosome dynamics. | ||||||
S-Trityl-L-cysteine | 2799-07-7 | sc-202799 sc-202799A | 1 g 5 g | $32.00 $66.00 | 6 | |
This compound inhibits the mitotic kinesin Eg5, impacting spindle dynamics and potentially influencing KIZ function indirectly by affecting centrosomal positioning and movement. | ||||||