C20orf19 Activators
Kizuna centrosomal protein, also known as KIZ or PLK1-interacting checkpoint helicase (PICH), is a protein that in humans is encoded by the KIZ gene. It is known to play a critical role in centrosome cohesion and function, which are essential for proper cell division and the maintenance of genomic stability. The centrosome is the primary microtubule-organizing center in animal cells and is pivotal for the formation of the bipolar spindle during mitosis.
KIZ is particularly noted for its function during mitosis, where it acts to maintain the integrity of the centrosome and ensure the proper segregation of chromosomes. It has been shown to interact with Polo-like kinase 1 (PLK1), a key regulator of mitotic progression, suggesting that KIZ may be involved in the PLK1-dependent pathways that regulate spindle dynamics and mitotic checkpoint signaling.Mutations or dysregulation of KIZ can lead to centrosomal abnormalities that may contribute to chromosomal instability, a hallmark of many cancer cells. This has drawn interest to KIZ as a potential biomarker for cancer prognosis and as a target for the development of novel cancer therapies. Furthermore, due to its role in the cell cycle, KIZ is also of interest in studies related to cell proliferation and developmental biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule dynamics, affecting spindle formation and potentially influencing centrosomal proteins like KIZ. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and could impact centrosome function and proteins like KIZ involved in cell division. | ||||||
BI6727 | 755038-65-4 | sc-364432 sc-364432A sc-364432B sc-364432C sc-364432D | 5 mg 50 mg 100 mg 500 mg 1 g | $147.00 $1029.00 $1632.00 $3264.00 $4296.00 | 1 | |
Polo-like kinase 1 (Plk1) is crucial for centrosome maturation and function; its inhibitors may affect proteins like KIZ. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
Aurora kinases play a key role in centrosome duplication and separation; inhibitors could impact KIZ function. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
Colchicine binds to tubulin and inhibits microtubule polymerization, affecting centrosome-related processes and potentially KIZ. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $92.00 $260.00 | 42 | |
Cyclin-dependent kinases (CDKs) are important for cell cycle regulation; CDK inhibitors might influence centrosome dynamics and KIZ. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
Proteasome inhibitors can affect various cell cycle proteins and may indirectly influence centrosome-associated proteins like KIZ. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Heat shock protein 90 (HSP90) plays a role in stabilizing several cell cycle proteins; its inhibitors might affect KIZ function. | ||||||
Vinblastine | 865-21-4 | sc-491749 sc-491749A sc-491749B sc-491749C sc-491749D | 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $230.00 $450.00 $1715.00 $2900.00 | 4 | |
Vinblastine inhibits microtubule formation and can disrupt centrosome function, potentially impacting proteins like KIZ. | ||||||