C1orf63 Activators
C1orf63 Activators are compounds that enhance the functional activity of C1orf63 through specific cellular and biochemical pathways. For instance, Epigallocatechin gallate (EGCG) and Resveratrol can promote the upregulation of C1orf63 by affecting gene expression regulation. EGCG inhibits DNA methyltransferases, leading to the upregulation of C1orf63, while Resveratrol activates SIRT1, which can increase the abundance of C1orf63 through deacetylation of associated transcription factors. Metformin and Sildenafil both modulate signaling pathways that influence the functional activity of C1orf63. Metformin activates AMPK, which can phosphorylate proteins that interact with C1orf63, while Sildenafil inhibits PDE5, enhancing the cGMP-PKG pathway that may phosphorylate proteins associated with C1orf63.
On the other hand, compounds like Curcumin and Quercetin modulate transcription factor activity, which can resultin an indirect upregulation of C1orf63's activity. Curcumin inhibits the NF-κB signaling pathway, leading to transcriptional changes that enhance the functional activity of C1orf63. Similarly, Quercetin's inhibition of PI3K can lead to alterations in the AKT signaling pathway, which can affect the activity of downstream proteins that interact with C1orf63. Sulforaphane, through its activation of the Nrf2 pathway, and Lithium, by inhibiting GSK-3β, both contribute to the regulation of transcriptional pathways that could result in increased expression and activity of C1orf63. PPARγ agonists such as Troglitazone and Pioglitazone also exert their effects through transcriptional regulation, leading to the enhancement of C1orf63 activity. Indole-3-carbinol affects estrogen receptor signaling, which may alter the transcription of genes interacting with C1orf63's functional pathways, while Capsaicin's activation of TRPV1 channels can initiate calcium-dependent signaling events that could enhance the activity of C1orf63.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea that can inhibit DNA methyltransferases, leading to hypomethylation and the potential upregulation of genes, including those encoding for C1orf63. This upregulation would enhance the functional activity of C1orf63 due to increased protein levels in the cell. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a stilbenoid that activates sirtuin 1 (SIRT1), an NAD+-dependent deacetylase. Activation of SIRT1 can lead to the deacetylation of transcription factors or co-factors involved in the expression of C1orf63, increasing its abundance and functional activity. | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
Metformin activates AMP-activated protein kinase (AMPK). Once activated, AMPK can phosphorylate downstream targets that are involved in the cellular pathways that regulate the function of C1orf63, leading to an increase in its activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit NF-κB signaling, which might result in the alteration of the transcriptional regulation of proteins, including the potential upregulation of C1orf63, thereby enhancing its functional activity in the cell. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid that inhibits PI3K, which in turn can modulate the AKT signaling pathway. This modulation can lead to the altered activity of downstream proteins that interact with or regulate C1orf63, resulting in enhanced activity of C1orf63. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which is involved in the cellular response to oxidative stress. Activation of Nrf2 can lead to the transcriptional activation of genes including those that may regulate the expression or function of C1orf63, enhancing its activity. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium inhibits GSK-3β, which leads to the stabilization of β-catenin. Stabilized β-catenin can translocate to the nucleus and influence Wnt target gene expression, potentially increasing the expression and activity of C1orf63. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $110.00 $204.00 $435.00 | 9 | |
Troglitazone activates PPARγ, which can lead to the transcriptional regulation of genes involved in the functional pathways of C1orf63, thereby enhancing the protein's functional activity. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $55.00 $125.00 | 13 | |
Pioglitazone, like troglitazone, is a PPARγ agonist that can influence the transcription of genes that are part of the signaling pathways regulating C1orf63, contributing to the enhancement of its functional activity. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol modulates estrogen receptor signaling, which can affect the transcription of genes that are part of the signaling pathways or cellular processes involving C1orf63, potentially enhancing its functional activity. | ||||||