C18orf37 Inhibitors
The INO80 complex subunit C, also known as INO80C, is a component of the INO80 chromatin remodeling complex, which plays a vital role in DNA-based processes within the nucleus of eukaryotic cells. INO80C is a highly conserved protein across various species, indicating its significance in cellular functions.The INO80 complex, where INO80C is a subunit, is involved in the regulation of transcription, DNA repair, and replication. It works by utilizing the energy from ATP hydrolysis to modify the positioning and composition of nucleosomes, which are the structural units of chromatin. This chromatin remodeling is crucial for allowing access of transcription factors and other DNA-binding proteins to genomic DNA.
INO80C's specific role within the INO80 complex is not as well characterized as the catalytic subunit INO80 itself, but it is believed to contribute to the structural integrity and functional regulation of the complex. It may also be involved in recruiting the INO80 complex to particular regions of chromatin, where it can then carry out its remodeling functions.Mutations or dysregulation of INO80C and other components of the INO80 complex have been implicated in cancer and other diseases because of their role in maintaining genomic stability. When cells are unable to properly modify chromatin structure, it can lead to errors in gene expression and DNA repair, contributing to the development of disease.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It alters chromatin structure and gene expression, potentially influencing the activity of chromatin remodeling complexes like INO80. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to affect various signaling pathways and can alter gene expression. It may indirectly influence INO80C by modifying the cellular environment and gene regulation. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
SAHA is another histone deacetylase inhibitor, affecting chromatin structure and potentially influencing the activity of chromatin remodeling complexes, including those with INO80C. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine, a known inhibitor of ATM and ATR kinases, might indirectly affect INO80C function by modulating the DNA damage response in which the INO80 complex is involved. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine can affect DNA repair mechanisms and autophagy. It might indirectly influence INO80C by altering the pathways where the INO80 complex plays a role. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine, a DNA methyltransferase inhibitor, affects DNA methylation and gene expression, potentially impacting the function of chromatin remodelers like the INO80 complex. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide has been shown to affect NF-κB signaling and might indirectly influence INO80C through alterations in transcriptional regulation and chromatin dynamics. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib, a PARP inhibitor, primarily targets DNA repair pathways. While it doesn't directly inhibit INO80C, it may impact related DNA repair processes in which INO80C is involved. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
NU7441 is a DNA-PK inhibitor, potentially affecting DNA repair pathways where the INO80 complex might be active, thereby indirectly influencing INO80C. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin, a PI3K inhibitor, also inhibits DNA-PK and could affect DNA repair mechanisms, potentially impacting INO80C function indirectly. | ||||||