C17orf83 Activators
C17orf83 Activators encompass a diverse array of chemical compounds that indirectly stimulate the functional activity of C17orf83 via distinct cellular signaling pathways. Forskolin and Sildenafil operate by increasing intracellular levels of cyclic nucleotides: forskolin elevates cAMP, which activates PKA, and sildenafil augments cGMP, potentially enhancing C17orf83's function through cGMP-dependent protein kinases or pathways. Ionomycin and A23187, both calcium ionophores, raise intracellular calcium concentrations, triggering calcium-dependent cascades that could lead to the activation of proteins that either interact with or regulate C17orf83, thus favoring its activity. Similarly, PMA activates PKC, which may indirectly promote C17orf83's activity by modulating proteins within its signaling network. Additionally, the kinase inhibitor EGCG and the GSK-3 inhibitor CHIR-99021 may potentiate C17orf83's functional role by attenuating competitive kinase pathways or stabilizing proteins that interact with the function of C17orf83.
The strategic modulation of key signaling molecules further characterizes the action of C17orf83 Activators. Compounds such as SB 203580 and U0126, which inhibit p38 MAPK and MEK respectively, could shift the balance of intracellular signaling towards pathways that C17orf83 is a part of, thereby enhancing its function. LY294002, a PI3K inhibitor, might also amplify C17orf83's activity by activating alternative routes that intersect with C17orf83-related pathways. Okadaic acid, by inhibiting protein phosphatases, induces a hyperphosphorylated state that could favor signaling events relevant to C17orf83's function. Zaprinast, akin to sildenafil, elevates cGMP levels and may enhance C17orf83 activity by affecting regulatory proteins associated with C17orf83. Collectively, these activators utilize a variety of mechanisms to influence the cellular environment and promote the functional activity of C17orf83 without directly increasing its expression or requiring its direct activation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, thereby activating calcium-dependent signaling pathways. This can lead to the activation of calcineurin and subsequent dephosphorylation of proteins that may interact with C17orf83, potentially enhancing its activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA functions as a protein kinase C (PKC) activator. PKC can phosphorylate proteins within the same signaling pathways as C17orf83, indirectly promoting its functional activity by altering the phosphorylation status of proteins that may modulate C17orf83 function or its interaction partners. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 is a p38 MAPK inhibitor that can shift cellular signaling pathways towards those that C17orf83 may be involved in. By inhibiting p38 MAPK, SB 203580 could indirectly reduce the phosphorylation of proteins that negatively regulate C17orf83, thus enhancing its functional activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can influence signaling pathways downstream of PI3K, such as the AKT pathway. Inhibition of PI3K can lead to the activation of alternative signaling routes that may intersect with pathways involving C17orf83, potentially resulting in enhanced activity of C17orf83. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that blocks the MAPK/ERK pathway. By inhibiting MEK, U0126 could indirectly activate proteins or pathways that are positively regulated by C17orf83 or that facilitate its functional activation, due to a shift in signaling dynamics. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels, similar to ionomycin. This elevation in calcium can activate calcium-dependent signaling pathways, which may enhance the functional activity of C17orf83 by affecting proteins or complexes that C17orf83 is part of. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibition properties. By inhibiting specific kinases, EGCG could potentiate signaling pathways that involve C17orf83 or increase its functional activity by reducing competitive signaling that would otherwise suppress C17orf83 activity. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
CHIR-99021 inhibits GSK-3, which may lead to the stabilization and activation of proteins within the Wnt signaling pathway. Even though C17orf83 is not directly involved in Wnt signaling, the downstream effects of GSK-3 inhibition could create a signaling environment that indirectly enhances the functional activity of C17orf83. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases can lead to increased phosphorylation levels within the cell, potentially enhancing signaling pathways that involve phosphorylation events relevant to C17orf83 activity. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast is another PDE5 inhibitor like sildenafil that increases intracellular cGMP levels, which can modulate signaling pathways potentially connected to C17orf83 and enhance its functional activity by interacting with regulatory proteins associated with C17orf83. | ||||||