C15orf44 Inhibitors
Integrator complex subunit 14 (INTS14) is a component of the integrator complex, a multiprotein assembly that plays a pivotal role in the processing of small nuclear RNAs (snRNAs), transcriptional regulation, and genome maintenance. INTS14 is one of the subunits of this complex and contributes to its diverse functions.The integrator complex is known for its essential role in the 3' end processing of uridine-rich small nuclear RNAs (U snRNAs), which are a component of the spliceosome, the cellular machinery responsible for the removal of introns from pre-messenger RNA (pre-mRNA). This processing is critical for the maturation of snRNAs, enabling them to form complexes with spliceosomal proteins and participate effectively in pre-mRNA splicing.
Beyond snRNA processing, INTS14 and the integrator complex are implicated in the regulation of gene expression at multiple levels. The complex has been shown to be associated with RNA polymerase II (Pol II) and is believed to play a role in transcription elongation as well as termination. It can influence chromatin architecture and has been linked to the regulation of enhancer RNAs (eRNAs), which are involved in the control of gene expression by enhancers.Recent studies suggest that the integrator complex, including INTS14, may also be involved in DNA repair and genome stability. The complex has been observed to localize to sites of DNA damage, suggesting a potential role in the cellular response to genotoxic stress.Alterations in the function or expression of INTS14 could have significant consequences for cell function and viability, potentially leading to diseases such as cancer. Given its involvement in fundamental cellular processes, INTS14 and the integrator complex are subjects of interest in the fields of molecular biology and pathology, with research ongoing to elucidate their roles in health and disease.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
α-Amanitin | 23109-05-9 | sc-202440 sc-202440A | 1 mg 5 mg | $269.00 $1050.00 | 26 | |
This potent inhibitor of RNA polymerase II halts mRNA synthesis, which could lead to a reduction in INTS14 expression. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
Triptolide inhibits the transcription of various genes by affecting RNA polymerase II activity, potentially reducing INTS14 levels. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
DRB is a kinase inhibitor that can impede RNA Pol II phosphorylation and thereby inhibit transcription initiation and elongation. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
By intercalating into DNA, Actinomycin D inhibits RNA polymerase movement, which can decrease INTS14 transcription. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $317.00 | ||
Flavopiridol inhibits cyclin-dependent kinases (CDKs) that are necessary for RNA polymerase II transcription. | ||||||
Cordycepin | 73-03-0 | sc-203902 | 10 mg | $101.00 | 5 | |
Cordycepin causes premature termination of mRNA synthesis possibly affecting INTS14 mRNA stability and expression. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
This compound can induce apoptosis and downregulate gene expression through various signaling pathways. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate transcription factors and signaling pathways, potentially leading to decreased INTS14 expression. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
Rocaglamide inhibits translation initiation and may indirectly reduce protein levels, including those of INTS14. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin interferes with peptide chain elongation during protein synthesis, which could reduce overall protein levels. | ||||||