C11orf74 Inhibitors
C11orf74 inhibitors, given the protein's known role in autophagy, largely pivot around modulating this intricate cellular process. Notably, a vast array of these inhibitors act upon the phosphatidylinositol 3-kinase (PI3K) pathways. Molecules such as 3-Methyladenine, Wortmannin, and LY294002 directly impede PI3K or its variants,steering C11orf74's functional activity within autophagy. On the other hand, Bafilomycin A1 and Chloroquine target the fusion of autophagosomes with lysosomes, a later stage in the autophagic process, thus indirectly delineating the overall functional context in which C11orf74 operates.
Moreover, considering mTOR's central regulatory role in autophagy, inhibitors like Torin1 and Rapamycin, or like MHY1485, bring forth a broader modulation of the autophagy landscape, which can in turn influence C11orf74's function. By adjusting the balance of autophagic flux through these chemical entities, one may achieve an indirect modulation of C11orf74 activity, making these compounds valuable tools for research into the protein's function and involvement in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
This molecule can inhibit class III PI3K, an early-stage player in autophagy, and by doing so, it may influence C11orf74 activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, and by blocking PI3K, it may affect C11orf74's role in autophagy. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Chloroquine inhibits the fusion of autophagosomes and lysosomes. This step is downstream of C11orf74's role, but it affects the overall autophagic process. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
By inhibiting the vacuolar ATPase, Bafilomycin A1 prevents the fusion of autophagosomes with lysosomes, potentially affecting C11orf74's functional relevance. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
This molecule promotes the degradation of Vps34 PI3K complexes, thus impacting the autophagic process and potentially C11orf74's function. | ||||||
SAR405 | 1523406-39-4 | sc-507416 | 1 mg | $125.00 | ||
SAR405 is a Vps34 inhibitor, affecting autophagy at early stages and possibly influencing C11orf74's activity. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Hydroxychloroquine, similar to Chloroquine, disrupts the fusion of autophagosomes with lysosomes, potentially affecting C11orf74’s function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 inhibits Class I PI3K, thus influencing the initiation stage of autophagy and C11orf74's role. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin1 directly targets mTOR, a central regulator of autophagy, thus affecting the pathway where C11orf74 operates. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, indirectly promoting autophagy. Its role can affect the broader pathway that C11orf74 is involved in. | ||||||