c-IAP1 Activators
C-IAP1 activators, short for cellular inhibitor of apoptosis protein 1 activators, represent a class of small molecules that play a crucial role in regulating programmed cell death, or apoptosis, within the human body. These activators are primarily characterized by their ability to modulate the function of c-IAP1, a protein belonging to the inhibitor of apoptosis (IAP) family. IAP proteins are essential components of the cellular machinery that controls apoptosis, a fundamental process that maintains tissue homeostasis by eliminating damaged or unwanted cells. C-IAP1, in particular, acts as a key player in this intricate regulatory network, exerting its influence by inhibiting the activity of caspases, a group of enzymes responsible for initiating and executing apoptosis.
C-IAP1 activators interact with c-IAP1 and can either enhance or attenuate its anti-apoptotic functions. By binding to c-IAP1, these molecules can modulate its activity, ultimately affecting the apoptotic cascade. This dual role in apoptosis regulation makes c-IAP1 activators essential components in understanding the fine-tuned balance between cell survival and cell death. In various physiological and pathological contexts, the manipulation of c-IAP1 activity by these activators can have profound effects on cell fate decisions, influencing processes such as tissue development, immune response, and cancer progression.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes and red wine, known for its antioxidant properties. It has been shown to activate the SIRT1 pathway, which can lead to the induction of c-IAP1 expression as part of its role in promoting cell survival. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a principal component of turmeric, possesses anti-inflammatory and antioxidant properties. It has been reported to increase c-IAP1 expression via NF-κB activation, contributing to its protective effects on cells. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It has been shown to induce the expression of various cytoprotective proteins, including c-IAP1, via the Nrf2 signaling pathway, contributing to its role in cellular defense against oxidative stress. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a flavonoid with antioxidant properties, found in many fruits and vegetables. It has been reported to increase c-IAP1 expression, potentially via activation of the PI3K/Akt and NF-κB pathways, aiding in cell survival and anti-apoptotic responses. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin has been shown to induce c-IAP1 expression as a cellular response to DNA damage. The increased c-IAP1 expression is thought to be a protective mechanism against cisplatin-induced apoptosis. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide can induce c-IAP1 expression as part of the cellular stress response. The increase in c-IAP1 expression is believed to play a role in the protection of cells from etoposide-induced apoptosis. | ||||||
Arsenic(III) oxide | 1327-53-3 | sc-210837 sc-210837A | 250 g 1 kg | $89.00 $228.00 | ||
Arsenic trioxide has been shown to induce c-IAP1 expression. The upregulation of c-IAP1 is thought to be a protective response against arsenic trioxide-induced oxidative stress and apoptosis. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
5-Fluorouracil ihas been reported to induce c-IAP1 expression in certain cell types. The induction of c-IAP1 is considered to be a part of the cellular response to the cytotoxic effects of 5-Fluorouracil. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a compound that induces ER stress, leading to the activation of survival pathways and an increase in c-IAP1 expression. The induction of c-IAP1 is thought to be a cellular protective response against ER stress. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor studied in the research of certain cancers. It has been reported to induce c-IAP1 expression, potentially as a cellular protective response against proteasome inhibition and the ensuing stress. | ||||||