Bub2 Activators
Bub2 is a protein prominently studied in yeast, particularly in the context of cell cycle regulation. It plays a crucial role in the mitotic exit network (MEN) and spindle assembly checkpoint (SAC), two critical pathways that ensure the proper segregation of chromosomes during cell division.Functioning as a GTPase-activating protein (GAP), Bub2 primarily targets Tem1, a small GTPase. This interaction is vital for controlling the timing of mitotic exit. The spindle assembly checkpoint, where Bub2 is actively involved, is a safeguard mechanism that blocks the cell from progressing to anaphase until all chromosomes are correctly attached to the spindle microtubules. This checkpoint ensures that the genetic material is accurately distributed between the daughter cells, thus maintaining genomic stability.
Bub2, along with its partner protein Bfa1, forms a complex that inhibits the MEN pathway. This inhibition is crucial in delaying the exit from mitosis under conditions where spindle alignment or attachment is faulty. By doing so, Bub2 ensures that cells do not proceed to the next phase of the cell cycle with unsegregated or damaged chromosomes, which could lead to aneuploidy or other forms of genomic instability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea induces replication stress, potentially enhancing Bub2 expression as part of the cell cycle checkpoint response. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule dynamics, possibly upregulating Bub2 in response to spindle assembly checkpoint activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR signaling, which might influence Bub2 expression in response to nutrient stress and cell growth regulation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin causes DNA damage, potentially triggering Bub2 expression as part of the DNA damage checkpoint response. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin induces DNA breaks, possibly enhancing Bub2 expression in response to genomic instability. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $56.00 $133.00 | 2 | |
MMS, an alkylating agent, could increase Bub2 expression due to its DNA-damaging effects. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide causes DNA breaks and could upregulate Bub2 as part of the cellular DNA damage response. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C induces DNA crosslinking, potentially enhancing Bub2 expression in response to impaired DNA replication. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin, by causing DNA damage, may trigger Bub2 expression in the DNA damage checkpoint pathway. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits DNA topoisomerase I, possibly inducing Bub2 expression due to replication stress and DNA damage. | ||||||