BTN2A1 Activators
BTN2A1 Activators are chemical agents that can indirectly modulate the protein BTN2A1 through diverse mechanisms. BTN2A1 plays a significant role in immune response and calcium signaling, and the compounds outlined in the selection primarily act to influence these functions. Agents such as Thapsigargin, A23187, Ionomycin, BAPTA-AM, and Cyclopiazonic Acid are key in this category as they alter intracellular calcium levels, triggering the calcium-signaling pathway and consequently influencing BTN2A1's performance in calcium-dependent processes.
Meanwhile, there are compounds that modulate BTN2A1 through the PI3K/AKT/mTOR and MAPK/ERK signaling pathways. LY294002, Wortmannin, and Rapamycin, for instance, are inhibitors of PI3K and mTOR. These compounds stop the activation of the AKT/mTOR pathway, which BTN2A1 is known to be affected by. Similarly, PD98059, U0126, SB203580, and SP600125 inhibit various components in the MAPK signaling pathway, including MEK, p38 MAPK, and JNK. By inhibiting these components, these compounds interfere with the pathway's activation, thereby indirectly modulating BTN2A1 function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) inhibitor, causing an increase in intracellular calcium levels. With BTN2A1's known function in modulating immune response through Ca2+ signaling, the rise in intracellular Ca2+ from thapsigargin activates the calcium-signaling pathway which BTN2A1 is involved in. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium levels. The increase in intracellular calcium levels can activate the calcium-signaling pathway, indirectly activating BTN2A1 as it plays a role in these calcium-dependent processes. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin, a calcium ionophore, increases intracellular calcium levels. The elevated calcium levels activate the calcium-signaling pathway, indirectly activating BTN2A1 due to its role in this pathway. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM is a calcium chelator that can alter intracellular calcium levels. By modulating calcium levels, BAPTA-AM can influence the calcium-signaling pathway and indirectly impact BTN2A1 activity, as BTN2A1 is involved in calcium-dependent processes. | ||||||
Cyclopiazonic Acid | 18172-33-3 | sc-201510 sc-201510A | 10 mg 50 mg | $176.00 $624.00 | 3 | |
Cyclopiazonic Acid is a specific inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). Inhibition of SERCA leads to an increase in cytosolic calcium concentration, which can activate the calcium-signaling pathway and indirectly impact BTN2A1. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. PI3K plays a critical role in activating downstream AKT/mTOR signaling pathway. By inhibiting PI3K, it prevents activation of AKT/mTOR pathway. As BTN2A1 function is known to be affected by AKT/mTOR signaling, LY294002 indirectly influences BTN2A1 function. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor. By inhibiting PI3K, it prevents activation of the AKT/mTOR signaling pathway. This indirectly impacts BTN2A1 function, as BTN2A1 activity is known to be modulated by this pathway. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MEK inhibitor that prevents the activation of MAPK/ERK signaling pathway. As BTN2A1 function is known to be affected by MAPK/ERK signaling, PD98059 indirectly influences BTN2A1 function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. By inhibiting p38 MAPK, it prevents activation of the MAPK signaling pathway. As BTN2A1 function is known to be affected by MAPK signaling, SB203580 indirectly influences BTN2A1 function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. By inhibiting JNK, it prevents activation of the MAPK signaling pathway. This can indirectly impact BTN2A1 function, as BTN2A1 activity is known to be modulated by this pathway. | ||||||