BSPRY Activators
BSPRY is a protein that can be activated through various biochemical mechanisms involving the modulation of intracellular secondary messenger systems and kinases. One primary route of BSPRY activation is through the elevation of cyclic AMP (cAMP) within the cell. Certain compounds are known to directly increase the activity of adenylyl cyclase or inhibit the degradation of cAMP, thus sustaining elevated levels of this secondary messenger. The resultant rise in cAMP activates protein kinase A (PKA), a kinase that phosphorylates a plethora of proteins, including BSPRY. The phosphorylation by PKA is a critical post-translational modification that leads to the functional activation of BSPRY, thereby influencing its role in cellular processes. Additionally, the activation of G protein-coupled receptors by specific ligands results in the production of cAMP, further perpetuating the activation cascade culminating in BSPRY phosphorylation.
Another mechanism by which BSPRY is activated involves the modulation of intracellular calcium levels. Calcium ionophores can increase the cytosolic concentration of calcium ions, which are crucial secondary messengers in cellular signaling. The surge in calcium levels can activate various calcium-dependent protein kinases that have the capability to phosphorylate BSPRY. Furthermore, the activation of protein kinase C (PKC) through certain diesters is known to phosphorylate a range of proteins, potentially including BSPRY. The concerted action of these calcium-dependent protein kinases and PKC can lead to the phosphorylation and activation of BSPRY.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
This diterpene acts directly on adenylyl cyclase, increasing cyclic AMP (cAMP) levels. Elevated cAMP enhances protein kinase A (PKA) activity, which can phosphorylate BSPRY, leading to its activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
As a synthetic beta-adrenergic agonist, it elevates intracellular cAMP levels, indirectly activating PKA. PKA then phosphorylates targets including BSPRY, resulting in increased BSPRY activity. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
A nonselective inhibitor of phosphodiesterases, IBMX prevents cAMP degradation, which sustains the activation of PKA. PKA, in turn, phosphorylates BSPRY, enhancing its activation. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
PGE2 works through its receptors to increase cAMP levels in cells, indirectly stimulating PKA and leading to subsequent phosphorylation and activation of BSPRY. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
As a calcium ionophore, it increases intracellular calcium levels, which can activate calcium-dependent protein kinases that may phosphorylate and activate BSPRY. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
This diester of phorbol acts as a protein kinase C (PKC) activator, which can phosphorylate a range of proteins, potentially including BSPRY, resulting in its activation. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A calcium ionophore, A23187 raises intracellular calcium, which could activate calcium-dependent kinases that phosphorylate BSPRY, leading to its activation. | ||||||
Adenosine 3′,5′-cyclic Monophosphate, N6-Benzoyl-, Sodium Salt | 30275-80-0 | sc-300167 | 10 µmol | $318.00 | 1 | |
A cAMP analog that activates PKA, leading to phosphorylation of target proteins such as BSPRY, thus promoting its activation. | ||||||
8-Bromo-cAMP | 76939-46-3 | sc-201564 sc-201564A | 10 mg 50 mg | $97.00 $224.00 | 30 | |
This cAMP analog triggers PKA activation, which then phosphorylates and activates BSPRY. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
A selective inhibitor of phosphodiesterase 4, rolipram increases cAMP levels, which activates PKA. PKA can phosphorylate BSPRY, enhancing its activation. | ||||||