BRPF3 Activators
BRPF3 inhibitors are a class of chemical compounds designed to target the BRPF3 protein, a key component of the MOZ, YBF2/SAS3, SAS2, and TIP60 (MYST) histone acetyltransferase complexes. BRPF3, along with other members of the bromodomain and PHD finger-containing (BRPF) family, plays a crucial role in epigenetic regulation by facilitating histone acetylation, a process essential for gene transcription. BRPF3 contains multiple functional domains, including bromodomains that recognize acetylated lysine residues on histones, allowing the complex to bind to chromatin and modify histone tails. By inhibiting BRPF3, these inhibitors disrupt the function of the MYST complexes, leading to potential alterations in gene expression patterns and cellular processes.
The development of BRPF3 inhibitors represents a significant advancement in the field of epigenetics and chromatin biology. These inhibitors provide researchers with a valuable tool to study the role of BRPF3 and its associated complexes in gene regulation and chromatin dynamics. Furthermore, BRPF3 inhibitors have the ability to uncover novel epigenetic targets for intervention in various diseases. Continued research into the mechanisms of BRPF3 inhibition and its effects on cellular function will further enhance our understanding of epigenetic regulation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
Histone deacetylase inhibitor that can promote a more relaxed chromatin state, possibly enhancing the recruitment and activity of BRPF3. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Inhibits histone deacetylase, leading to hyperacetylation of histones, which may facilitate the activity of BRPF3-associated HAT complexes. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Histone deacetylase inhibitor that can lead to an open chromatin configuration, potentially aiding BRPF3 function. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
Inhibits SIRT1 deacetylase, potentially enhancing the acetylation levels of histones and assisting BRPF3 activity. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Inhibits histone acetyltransferase p300 and could indirectly affect the balance of histone acetylation, impacting BRPF3 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Modulates histone acetylation and could thereby affect the recruitment and activity of BRPF3 on chromatin. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $214.00 $247.00 $1463.00 | 2 | |
A selective inhibitor of HDACs, which may create a chromatin state that facilitates BRPF3 function. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
A histone methyltransferase inhibitor that alters chromatin marks, which could impact BRPF3 activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor, leading to demethylation and a more open chromatin structure, potentially affecting BRPF3. | ||||||
Garcinol | 78824-30-3 | sc-200891 sc-200891A | 10 mg 50 mg | $124.00 $502.00 | 13 | |
Inhibits p300 HAT activity, possibly affecting chromatin acetylation states and thereby BRPF3 function. | ||||||