BRAF35 Activators
High Mobility Group 20B (HMG20B), also known as iBRAF, is a protein that plays a significant role in the regulation of gene expression and chromatin structure. As part of the high mobility group of proteins, HMG20B is characterized by its ability to bind to DNA and influence chromatin dynamics, thereby impacting various cellular processes.HMG20B is known for its involvement in neuronal differentiation. It interacts with factors like the LSD1/CoREST/HDAC complex, playing a crucial role in the regulation of neuronal genes. This interaction is essential for the development and maturation of neurons, highlighting the importance of HMG20B in neurodevelopment.
Additionally, HMG20B has been implicated in other cellular processes, including the regulation of cell cycle and maintenance of genomic stability. Its role in these processes is linked to its ability to modulate chromatin structure, which is crucial for accurate DNA replication and repair.Research has also suggested an involvement of HMG20B in cancer. Alterations in its expression or function could contribute to the development and progression of certain types of cancer, although this area requires further investigation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
May induce DNA replication stress, potentially upregulating BRAF35 as part of the cellular repair mechanism. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Known to cause DNA crosslinking, which could lead to the activation of DNA repair pathways involving BRAF35. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
As an anthracycline antibiotic, it intercalates DNA, possibly triggering a stress response that includes BRAF35 expression. | ||||||
Methyl methanesulfonate | 66-27-3 | sc-250376 sc-250376A | 5 g 25 g | $55.00 $130.00 | 2 | |
A DNA alkylating agent that can cause DNA damage, potentially enhancing BRAF35 expression in response. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Causes DNA strand breaks, which may upregulate BRAF35 as part of the DNA damage response. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I, leading to DNA damage and possible upregulation of BRAF35. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Incorporated into RNA and DNA, causing damage and potentially increasing BRAF35 expression. | ||||||
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $270.00 | 5 | |
Induces DNA breaks, potentially triggering a DNA damage response involving BRAF35. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
Crosslinks DNA, potentially enhancing BRAF35 expression as part of the cellular response to DNA damage. | ||||||
Oxaliplatin | 61825-94-3 | sc-202270 sc-202270A | 5 mg 25 mg | $110.00 $386.00 | 8 | |
Causes DNA crosslinking, which may lead to increased BRAF35 expression in response to DNA damage. | ||||||