Bpifa6 Activators
Bpifa6, encoding a secreted protein, plays a crucial role in mucosal defense mechanisms, particularly in the respiratory tract. The protein is involved in the regulation of immune responses and maintenance of epithelial integrity. Activation of Bpifa6 is intricately linked to epigenetic modifications and signaling cascades. Chemical activators, such as histone deacetylase inhibitors (Sodium Butyrate, Trichostatin A, Valproic Acid) and retinoic acid receptor agonists (Retinoic Acid), directly impact the chromatin structure, facilitating increased accessibility of the Bpifa6 promoter and subsequent gene expression.
Additionally, agents like Forskolin, 12-O-Tetradecanoylphorbol-13-acetate (TPA), and A23187 activate Bpifa6 through signaling cascades involving cAMP elevation, protein kinase C activation, and calcium-dependent pathways, respectively. These pathways lead to phosphorylation events and modifications in chromatin structure, enhancing the availability of the gene promoter for transcriptional machinery. The involvement of sirtuin activators (Resveratrol), DNA methyltransferase inhibitors (5-Azacytidine), and GABA receptor modulators (Sodium Valproate) further emphasizes the complexity of Bpifa6 regulation through epigenetic modifications. In summary, Bpifa6 activation is a finely tuned process involving multiple chemicals that modulate chromatin structure and signaling pathways, contributing to its role in mucosal immunity and epithelial function.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor impacting chromatin structure, promoting Bpifa6 expression. Activation is achieved through increased accessibility of the gene promoter, facilitating enhanced transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor influencing chromatin structure, leading to increased accessibility of the Bpifa6 promoter. Activation is achieved by enhancing the transcriptional machinery's access to the gene. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid receptor agonist influencing gene transcription. Bpifa6 is a target of retinoic acid, and activation involves ligand-receptor complex binding to specific response elements in its promoter. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Adenylyl cyclase activator elevating cAMP levels, triggering PKA signaling. Bpifa6 activation occurs through cAMP-responsive elements in its promoter, facilitating increased gene expression. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Protein kinase C activator initiating signaling cascades. Bpifa6 activation is achieved through downstream kinase-mediated phosphorylation events, enhancing the accessibility of the gene promoter. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $30.00 $115.00 $900.00 | 136 | |
Solvent with potential epigenetic effects, influencing Bpifa6 expression indirectly. DMSO can modulate chromatin structure, affecting transcription factor binding and thereby impacting the gene's activation. | ||||||
Butyric acid | 107-92-6 | sc-214640 sc-214640A | 1 kg 10 kg | $63.00 $174.00 | ||
Short-chain fatty acid influencing histone acetylation and chromatin structure. Bpifa6 activation is achieved through epigenetic modifications, facilitating an open chromatin state and increased gene expression. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
Calcium ionophore activating signaling cascades. Bpifa6 activation involves calcium-dependent pathways, leading to phosphorylation events and enhanced accessibility of the gene promoter for transcription. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Histone deacetylase inhibitor altering chromatin conformation, promoting Bpifa6 expression. Activation is mediated through epigenetic modifications facilitating increased accessibility of the gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Sirtuin activator influencing histone deacetylation. Bpifa6 activation is mediated through sirtuin-dependent epigenetic modifications, leading to an open chromatin state and enhanced accessibility of the gene promoter. | ||||||