Date published: 2025-10-3

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BNC1 Activators

BNC1 Activators encompass a range of chemical compounds that indirectly elevate the functional activity of BNC1 through diverse signaling pathways and cellular mechanisms. Compounds such as Forskolin and Dibutyryl-cAMP function by raising intracellular cAMP levels, thereby catalyzing the phosphorylation of transcriptional partners that may work in concert with BNC1, enhancing its gene regulatory effects. Histone deacetylase inhibitors like Trichostatin A and DNA methyltransferase inhibitors such as 5-Azacytidine alter the chromatin landscape, improving BNC1's access to DNA and augmenting its transcriptional impact. Similarly, agents like Phorbol 12-myristate 13-acetate (PMA) activate PKC, which may phosphorylate intermediary proteins that assist BNC1 in exerting its gene expression control. The actions of kinase inhibitors such as Epigallocatechin gallate (EGCG), LY294002, SB203580, and U0126 contribute to the activation of BNC1 by modifying the phosphorylation state of proteins within signaling networks that BNC1 is part of, thus influencing its transcriptional regulation capabilities.

Additionally, Sphingosine-1-phosphate and Retinoic acid are known to modulate the expression of genes and chromatin architecture, which could potentiate BNC1's ability to regulate itstarget genes by facilitating access to the DNA. Sphingosine-1-phosphate, in particular, may enhance BNC1's functional role by influencing epigenetic modifications and gene expression patterns that are conducive to BNC1 activity. Retinoic acid, with its capacity to affect transcription through retinoic acid receptors, can indirectly enhance BNC1's activity by affecting the transcriptional machinery to which BNC1 is connected. Calcium signaling, modulated by the ionophore A23187 (Calcimycin), also plays a critical role in the regulation of various cellular processes, including those that may involve BNC1, by potentially supporting calcium-dependent transcriptional events that synergize with BNC1's role in gene regulation. Collectively, these BNC1 Activators, through their targeted influence on cellular signaling pathways and transcriptional modulation, facilitate the enhancement of BNC1's regulatory functions within the cell without necessitating an increase in its expression or direct activation.

SEE ALSO...

Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Forskolin activates adenylate cyclase, increasing intracellular cAMP levels, which enhances BNC1 activity by promoting the phosphorylation of transcription factors that can cooperate with BNC1 in gene regulation.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Trichostatin A is a histone deacetylase inhibitor that leads to a more relaxed chromatin state, potentially facilitating BNC1 binding to DNA and enhancing its transcriptional activity.

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

As a DNA methyltransferase inhibitor, 5-Azacytidine reduces DNA methylation, which might increase BNC1's access to its target genes and boost its transcriptional regulation.

PMA

16561-29-8sc-3576
sc-3576A
sc-3576B
sc-3576C
sc-3576D
1 mg
5 mg
10 mg
25 mg
100 mg
$40.00
$129.00
$210.00
$490.00
$929.00
119
(6)

PMA activates protein kinase C (PKC) which can phosphorylate proteins that interact with BNC1, thereby enhancing BNC1's ability to regulate gene expression.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$42.00
$72.00
$124.00
$238.00
$520.00
$1234.00
11
(1)

EGCG inhibits several protein kinases and could reduce competitive signaling, potentially enhancing BNC1-mediated transcriptional activity by altering the phosphorylation status of associated co-regulators.

LY 294002

154447-36-6sc-201426
sc-201426A
5 mg
25 mg
$121.00
$392.00
148
(1)

LY294002 is a PI3K inhibitor that might enhance BNC1 activity by modulating transcription factors and co-regulators in the PI3K/Akt pathway that interact with BNC1.

SB 203580

152121-47-6sc-3533
sc-3533A
1 mg
5 mg
$88.00
$342.00
284
(5)

By inhibiting p38 MAPK, SB203580 could shift the signaling equilibrium in favor of pathways that enhance BNC1's role in transcription regulation.

U-0126

109511-58-2sc-222395
sc-222395A
1 mg
5 mg
$63.00
$241.00
136
(2)

U0126 inhibits MEK1/2, potentially favoring BNC1's transcriptional activity by impacting the phosphorylation status of proteins that co-regulate genes with BNC1.

D-erythro-Sphingosine-1-phosphate

26993-30-6sc-201383
sc-201383D
sc-201383A
sc-201383B
sc-201383C
1 mg
2 mg
5 mg
10 mg
25 mg
$162.00
$316.00
$559.00
$889.00
$1693.00
7
(1)

Sphingosine-1-phosphate can modulate chromatin structure and gene expression, possibly enhancing BNC1's ability to access and regulate target gene promoters.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

Retinoic acid influences gene expression through retinoic acid receptors, which can form heterodimers with other transcription factors and co-regulators potentially involved in BNC1-mediated transcription.