BNC1 Activators encompass a range of chemical compounds that indirectly elevate the functional activity of BNC1 through diverse signaling pathways and cellular mechanisms. Compounds such as Forskolin and Dibutyryl-cAMP function by raising intracellular cAMP levels, thereby catalyzing the phosphorylation of transcriptional partners that may work in concert with BNC1, enhancing its gene regulatory effects. Histone deacetylase inhibitors like Trichostatin A and DNA methyltransferase inhibitors such as 5-Azacytidine alter the chromatin landscape, improving BNC1's access to DNA and augmenting its transcriptional impact. Similarly, agents like Phorbol 12-myristate 13-acetate (PMA) activate PKC, which may phosphorylate intermediary proteins that assist BNC1 in exerting its gene expression control. The actions of kinase inhibitors such as Epigallocatechin gallate (EGCG), LY294002, SB203580, and U0126 contribute to the activation of BNC1 by modifying the phosphorylation state of proteins within signaling networks that BNC1 is part of, thus influencing its transcriptional regulation capabilities.
Additionally, Sphingosine-1-phosphate and Retinoic acid are known to modulate the expression of genes and chromatin architecture, which could potentiate BNC1's ability to regulate itstarget genes by facilitating access to the DNA. Sphingosine-1-phosphate, in particular, may enhance BNC1's functional role by influencing epigenetic modifications and gene expression patterns that are conducive to BNC1 activity. Retinoic acid, with its capacity to affect transcription through retinoic acid receptors, can indirectly enhance BNC1's activity by affecting the transcriptional machinery to which BNC1 is connected. Calcium signaling, modulated by the ionophore A23187 (Calcimycin), also plays a critical role in the regulation of various cellular processes, including those that may involve BNC1, by potentially supporting calcium-dependent transcriptional events that synergize with BNC1's role in gene regulation. Collectively, these BNC1 Activators, through their targeted influence on cellular signaling pathways and transcriptional modulation, facilitate the enhancement of BNC1's regulatory functions within the cell without necessitating an increase in its expression or direct activation.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels, which enhances BNC1 activity by promoting the phosphorylation of transcription factors that can cooperate with BNC1 in gene regulation. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that leads to a more relaxed chromatin state, potentially facilitating BNC1 binding to DNA and enhancing its transcriptional activity. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
As a DNA methyltransferase inhibitor, 5-Azacytidine reduces DNA methylation, which might increase BNC1's access to its target genes and boost its transcriptional regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC) which can phosphorylate proteins that interact with BNC1, thereby enhancing BNC1's ability to regulate gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG inhibits several protein kinases and could reduce competitive signaling, potentially enhancing BNC1-mediated transcriptional activity by altering the phosphorylation status of associated co-regulators. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that might enhance BNC1 activity by modulating transcription factors and co-regulators in the PI3K/Akt pathway that interact with BNC1. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
By inhibiting p38 MAPK, SB203580 could shift the signaling equilibrium in favor of pathways that enhance BNC1's role in transcription regulation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 inhibits MEK1/2, potentially favoring BNC1's transcriptional activity by impacting the phosphorylation status of proteins that co-regulate genes with BNC1. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate can modulate chromatin structure and gene expression, possibly enhancing BNC1's ability to access and regulate target gene promoters. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences gene expression through retinoic acid receptors, which can form heterodimers with other transcription factors and co-regulators potentially involved in BNC1-mediated transcription. |