BMPR-II Activators, short for Bone Morphogenetic Protein Receptor Type II Activators, represent a class of small molecules and compounds that play a pivotal role in regulating cellular signaling pathways associated with bone morphogenetic proteins (BMPs). BMPs are a group of multifunctional growth factors that control various cellular processes, including embryonic development, tissue homeostasis, and organogenesis. BMPR-II, or Bone Morphogenetic Protein Receptor Type II, is a transmembrane receptor protein located on the cell surface, primarily found in bone and other tissues. BMPR-II serves as a crucial component in the BMP signaling pathway, initiating a cascade of molecular events upon activation by BMP ligands. BMPR-II Activators, therefore, refer to substances that enhance or facilitate the activation of BMPR-II and, consequently, the downstream signaling events associated with BMPs.
These activators exert their effects by modulating the interaction between BMP ligands and BMPR-II, leading to increased receptor activation and subsequent downstream responses. They can work through various mechanisms, such as stabilizing the ligand-receptor complex, enhancing receptor phosphorylation, or promoting the recruitment of downstream signaling molecules. By promoting BMP signaling, BMPR-II Activators contribute to the regulation of essential cellular processes like cell differentiation, proliferation, and apoptosis, with potential implications in various physiological and pathological contexts.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
This synthetic glucocorticoid may enhance BMPR-II expression through its anti-inflammatory effects and modulation of gene transcription. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
As a vitamin A derivative, it potentially regulates cell growth and differentiation, influencing BMPR-II expression in various cell types. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
This demethylating agent may induce BMPR-II expression by reversing epigenetic silencing of the gene. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Known to elevate intracellular cAMP levels, forskolin might promote BMPR-II expression through cAMP-dependent pathways. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
As a principal estrogen, it could modulate BMPR-II expression in a hormone-dependent manner across different tissues. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
This histone deacetylase inhibitor may upregulate BMPR-II by altering chromatin structure and making the gene more accessible for transcription. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
It is known to regulate gene expression, and it might influence BMPR-II expression in a context-dependent manner. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Extracted from turmeric, curcumin may have a regulatory role on BMPR-II expression through its anti-inflammatory and antioxidant properties. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
This polyphenol, found in red wine, may influence BMPR-II expression through its effects on sirtuins and longevity-associated pathways. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
As a histone deacetylase inhibitor, sodium butyrate might enhance BMPR-II expression by promoting a more open chromatin state. |