Date published: 2025-10-20

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BMPR-II Activators

BMPR-II Activators, short for Bone Morphogenetic Protein Receptor Type II Activators, represent a class of small molecules and compounds that play a pivotal role in regulating cellular signaling pathways associated with bone morphogenetic proteins (BMPs). BMPs are a group of multifunctional growth factors that control various cellular processes, including embryonic development, tissue homeostasis, and organogenesis. BMPR-II, or Bone Morphogenetic Protein Receptor Type II, is a transmembrane receptor protein located on the cell surface, primarily found in bone and other tissues. BMPR-II serves as a crucial component in the BMP signaling pathway, initiating a cascade of molecular events upon activation by BMP ligands. BMPR-II Activators, therefore, refer to substances that enhance or facilitate the activation of BMPR-II and, consequently, the downstream signaling events associated with BMPs.

These activators exert their effects by modulating the interaction between BMP ligands and BMPR-II, leading to increased receptor activation and subsequent downstream responses. They can work through various mechanisms, such as stabilizing the ligand-receptor complex, enhancing receptor phosphorylation, or promoting the recruitment of downstream signaling molecules. By promoting BMP signaling, BMPR-II Activators contribute to the regulation of essential cellular processes like cell differentiation, proliferation, and apoptosis, with potential implications in various physiological and pathological contexts.

SEE ALSO...

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$76.00
$82.00
$367.00
36
(1)

This synthetic glucocorticoid may enhance BMPR-II expression through its anti-inflammatory effects and modulation of gene transcription.

Retinoic Acid, all trans

302-79-4sc-200898
sc-200898A
sc-200898B
sc-200898C
500 mg
5 g
10 g
100 g
$65.00
$319.00
$575.00
$998.00
28
(1)

As a vitamin A derivative, it potentially regulates cell growth and differentiation, influencing BMPR-II expression in various cell types.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$214.00
$316.00
$418.00
7
(1)

This demethylating agent may induce BMPR-II expression by reversing epigenetic silencing of the gene.

Forskolin

66575-29-9sc-3562
sc-3562A
sc-3562B
sc-3562C
sc-3562D
5 mg
50 mg
1 g
2 g
5 g
$76.00
$150.00
$725.00
$1385.00
$2050.00
73
(3)

Known to elevate intracellular cAMP levels, forskolin might promote BMPR-II expression through cAMP-dependent pathways.

β-Estradiol

50-28-2sc-204431
sc-204431A
500 mg
5 g
$62.00
$178.00
8
(1)

As a principal estrogen, it could modulate BMPR-II expression in a hormone-dependent manner across different tissues.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

This histone deacetylase inhibitor may upregulate BMPR-II by altering chromatin structure and making the gene more accessible for transcription.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$70.00
$160.00
$290.00
2
(1)

It is known to regulate gene expression, and it might influence BMPR-II expression in a context-dependent manner.

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$36.00
$68.00
$107.00
$214.00
$234.00
$862.00
$1968.00
47
(1)

Extracted from turmeric, curcumin may have a regulatory role on BMPR-II expression through its anti-inflammatory and antioxidant properties.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$60.00
$185.00
$365.00
64
(2)

This polyphenol, found in red wine, may influence BMPR-II expression through its effects on sirtuins and longevity-associated pathways.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$30.00
$46.00
$82.00
$218.00
19
(3)

As a histone deacetylase inhibitor, sodium butyrate might enhance BMPR-II expression by promoting a more open chromatin state.