beta1-AR Inhibitors
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Items 31 to 40 of 40 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $94.00 $141.00 | ||
Although primarily a β2-agonist, Salbutamol has been shown to have off-target effects on β1-AR, leading to its activation. This can result in increased cyclic AMP and PKA activity, enhancing cardiac contractility and rate to a lesser extent. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $92.00 $378.00 | 2 | |
Terbutaline, like Salbutamol, is a β2-adrenergic receptor agonist with minor agonistic effects on β1-AR, leading to indirect activation of β1-AR and subsequent increase in cyclic AMP and PKA activity, which can enhance heart rate and contractility. | ||||||
(−)-Nebivolol | 118457-16-2 | sc-212366 | 1 mg | $448.00 | ||
(-)-Nebivolol is a selective beta-1 adrenergic receptor modulator characterized by its unique ability to enhance nitric oxide release, promoting vasodilation. Its chiral structure allows for specific stereochemical interactions that influence receptor conformation and signaling pathways. The compound exhibits a prolonged half-life, enabling sustained receptor engagement. Additionally, its lipophilic nature aids in membrane permeability, enhancing its interaction dynamics within cellular environments. | ||||||
rac Propranolol β-D-Glucuronide Sodium Salt | 66322-66-5 non-salt | sc-219873 | 1 mg | $380.00 | ||
Rac Propranolol β-D-Glucuronide Sodium Salt exhibits intriguing molecular behavior as a beta-1 adrenergic receptor modulator. Its glucuronide conjugation enhances hydrophilicity, promoting solubility and facilitating transport across biological membranes. The compound's unique stereochemical arrangement allows for selective receptor engagement, influencing downstream signaling pathways. Its reaction kinetics are characterized by a balance between rapid binding and prolonged receptor occupancy, contributing to its distinct pharmacodynamic profile. | ||||||
Sotalol hydrochloride | 959-24-0 | sc-203699 sc-203699A | 10 mg 50 mg | $68.00 $251.00 | 3 | |
Sotalol is a non-selective β1-AR blocker with additional class III antiarrhythmic properties. | ||||||
4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzaldehyde | 29122-74-5 | sc-209893 | 5 mg | $320.00 | ||
4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzaldehyde acts as a beta-1 adrenergic receptor agonist, exhibiting unique binding affinity due to its hydroxyl and alkyl substituents. This compound facilitates distinct conformational changes in the receptor, influencing downstream signaling cascades. Its structural features promote effective hydrogen bonding and hydrophobic interactions, enhancing receptor activation kinetics. The compound's solubility profile supports its dynamic behavior in various biological environments, contributing to its functional versatility. | ||||||
rac Talinolol | 57460-41-0 | sc-212743 | 5 mg | $237.00 | ||
Rac Talinolol is a selective beta-1 adrenergic receptor antagonist characterized by its unique stereochemistry, which influences its binding dynamics. The compound's distinct molecular architecture allows for specific interactions with receptor sites, stabilizing the active conformation. Its kinetic profile reveals a rapid onset of action, attributed to efficient molecular docking and conformational adaptability. Additionally, the presence of functional groups enhances its solubility, facilitating diverse interactions in biological systems. | ||||||
(+)-Nebivolol | 118457-15-1 | sc-212367 | 0.5 mg | $510.00 | ||
(+)-Nebivolol is a selective beta-1 adrenergic receptor antagonist known for its unique enantiomeric structure, which enhances its affinity for the receptor. This compound exhibits a distinct mechanism of action by promoting vasodilation through nitric oxide release, influencing cardiovascular function. Its stereochemistry allows for specific interactions with receptor sites, leading to tailored signaling cascades. The compound's kinetic profile is marked by a gradual onset of action, ensuring sustained receptor engagement. | ||||||
CGP-20712A methanesulfonate salt | 105737-62-0 | sc-507239 | 10 mg | $315.00 | ||
CGP-20712A methanesulfonate salt is a selective beta1-adrenergic receptor agonist, notable for its high affinity and specificity towards beta1-ARs. Its unique molecular interactions promote distinct signaling pathways, influencing intracellular cAMP levels and downstream effects. The compound's kinetic profile reveals rapid receptor binding and dissociation, contributing to its dynamic pharmacological behavior. Additionally, its solubility characteristics enhance its compatibility in various biochemical assays. | ||||||
rac Metoprolol-d7 | 51384-51-1 (unlabeled) | sc-219857 | 1 mg | $380.00 | ||
Rac Metoprolol-d7 is a deuterated variant of Metoprolol, characterized by its unique isotopic labeling that enhances its stability and metabolic tracking. This compound exhibits selective binding to beta-1 adrenergic receptors, facilitating specific conformational changes that modulate receptor activity. Its distinct isotopic composition influences reaction kinetics, allowing for precise studies of metabolic pathways and receptor interactions, while its physical properties may alter solubility and distribution in biological systems. | ||||||