Date published: 2026-5-16
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(+)-Nebivolol (CAS 118457-15-1) - chemical structure image
Molecular structure of (+)-Nebivolol, CAS Number: 118457-15-1
(+)-Nebivolol (CAS 118457-15-1) - chemical structure image
Molecular structure of (+)-Nebivolol, CAS Number: 118457-15-1
Molecular structure of (+)-Nebivolol, CAS Number: 118457-15-1

(+)-Nebivolol (CAS 118457-15-1)

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Alternate Names:
(αR,αR,2R,2S)-α,α-[Iminobis(methylene)]bis[6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol]
Application:
(+)-Nebivolol is a β1-Adrenergic blocker
CAS Number:
118457-15-1
Molecular Weight:
405.44
Molecular Formula:
C22H25F2NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SDS & Certificate of Analysis

(+)-Nebivolol is a beta-adrenergic antagonist that functions by selectively blocking beta-1 adrenergic receptors in the heart and blood vessels. This action results in a reduction of heart rate and blood pressure, making it useful for studying cardiovascular function and regulation. At the molecular level, (+)-Nebivolol inhibits the binding of norepinephrine and epinephrine to beta-1 adrenergic receptors, thereby preventing the activation of downstream signaling pathways involved in regulating heart rate and vascular tone. (+)-Nebivolol′s mechanism of action involves its specific interaction with beta-1 adrenergic receptors, leading to a decrease in sympathetic nervous system activity and subsequent cardiovascular effects. (+)-Nebivolol′s ability to modulate beta-1 adrenergic receptor activity provides for investigating the physiological and pathophysiological processes related to cardiovascular function and regulation.


(+)-Nebivolol (CAS 118457-15-1) References

  1. Nebivolol in the management of essential hypertension: a review.  |  McNeely, W. and Goa, KL. 1999. Drugs. 57: 633-51. PMID: 10235696
  2. Nebivolol: endothelium-mediated vasodilating effect.  |  Ritter, JM. 2001. J Cardiovasc Pharmacol. 38 Suppl 3: S13-6. PMID: 11811387
  3. Nebivolol: a review of its clinical and pharmacological characteristics.  |  Gielen, W., et al. 2006. Int J Clin Pharmacol Ther. 44: 344-57. PMID: 16961165
  4. Stereochemical comparison of nebivolol with other beta-blockers.  |  Siebert, CD., et al. 2008. Chirality. 20: 103-9. PMID: 18072266
  5. Nebivolol in the treatment of chronic heart failure.  |  Veverka, A. and Salinas, JL. 2007. Vasc Health Risk Manag. 3: 647-54. PMID: 18078016
  6. Nebivolol: pharmacologic profile of an ultraselective, vasodilatory beta1-blocker.  |  Prisant, LM. 2008. J Clin Pharmacol. 48: 225-39. PMID: 18083889
  7. A review of the safety and efficacy of nebivolol in the mildly hypertensive patient.  |  Cockcroft, J. 2007. Vasc Health Risk Manag. 3: 909-17. PMID: 18200810
  8. Nebivolol: more than a highly selective Beta blocker.  |  Karter, Y. 2007. Recent Pat Cardiovasc Drug Discov. 2: 152-5. PMID: 18221115
  9. Nebivolol: a highly selective beta1-adrenergic receptor blocker that causes vasodilation by increasing nitric oxide.  |  Gupta, S. and Wright, HM. 2008. Cardiovasc Ther. 26: 189-202. PMID: 18786089
  10. [Nebivolol: the first vasodilatory beta-blocker with a beta3-adrenergic agonist activity].  |  Gauthier, C. and Trochu, JN. 2010. Ann Cardiol Angeiol (Paris). 59: 155-9. PMID: 20620250
  11. A Review of Nebivolol Pharmacology and Clinical Evidence.  |  Fongemie, J. and Felix-Getzik, E. 2015. Drugs. 75: 1349-71. PMID: 26177892
  12. Nebivolol alleviates liver damage caused by methotrexate via AKT1/Hif1α/eNOS signaling.  |  Pekgöz, S., et al. 2022. Drug Chem Toxicol. 45: 2153-2159. PMID: 34693844
  13. Nebivolol Sensitizes BT-474 Breast Cancer Cells to FGFR Inhibitors.  |  Kim, YJ., et al. 2023. Anticancer Res. 43: 1973-1980. PMID: 37097659

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(+)-Nebivolol, 0.5 mg

sc-212367
0.5 mg
$510.00
1-800-457-3801
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