Date published: 2025-10-17

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(−)-Nebivolol (CAS 118457-16-2)

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Application:
(−)-Nebivolol is a β1-Adrenergic blocker
CAS Number:
118457-16-2
Purity:
98%
Molecular Weight:
405.44
Molecular Formula:
C22H25F2NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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(−)-Nebivolol is a beta-adrenergic antagonist that functions by selectively blocking beta-1 adrenergic receptors in the heart and blood vessels. This action results in a reduction of heart rate and blood pressure, which may be useful for studying cardiovascular function and regulation. At the molecular level, (−)-Nebivolol inhibits the binding of norepinephrine and epinephrine to beta-1 adrenergic receptors, thereby preventing the activation of these receptors and the subsequent downstream signaling pathways. This chemical′s mode of action involves specifically targeting and modulating the activity of beta-1 adrenergic receptors, which are crucial for regulating cardiac function and vascular tone. By interfering with these receptors, (−)-Nebivolol can provide insights into the physiological and pathological processes associated with cardiovascular diseases, may be useful for research in this field.


(−)-Nebivolol (CAS 118457-16-2) References

  1. Blockade of ß-Adrenergic Receptors by Nebivolol Enables Tumor Control Potential for Uveal Melanoma in 3D Tumor Spheroids and 2D Cultures.  |  Farhoumand, LS., et al. 2023. Int J Mol Sci. 24: PMID: 36982966

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

(−)-Nebivolol, 1 mg

sc-212366
1 mg
$439.00