rac Talinolol (CAS 57460-41-0)
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rac Talinolol is a compound of interest in pharmacokinetic studies due to its properties as a beta-adrenergic blocker. Research often focuses on its interaction with efflux transporters like P-glycoprotein, which can influence chemical absorption and disposition. In the field of biochemistry, rac Talinolol is used to understand the modulation of adrenergic receptors and the subsequent impact on cellular signaling pathways. Additionally, it serves as a model compound in the investigation of stereoselective chemical disposition, as the racemic mixture provides both enantiomers for comparative studies. Studies involving rac Talinolol also encompass its effects on cardiac cells, particularly in the context of its action on ion channels and the resulting changes in electrophysiological properties.
rac Talinolol (CAS 57460-41-0) References
- Grapefruit juice enhances intestinal absorption of the P-glycoprotein substrate talinolol. | Spahn-Langguth, H. and Langguth, P. 2001. Eur J Pharm Sci. 12: 361-7. PMID: 11231102
- Pretreatment with potent P-glycoprotein ligands may increase intestinal secretion in rats. | Hanafy, A., et al. 2001. Eur J Pharm Sci. 12: 405-15. PMID: 11231107
- Evidence for intestinal secretion as an additional clearance pathway of talinolol enantiomers: concentration- and dose-dependent absorption in vitro and in vivo. | Wetterich, U., et al. 1996. Pharm Res. 13: 514-22. PMID: 8710739
- Characterization of binding properties to human P-glycoprotein: development of a [3H]verapamil radioligand-binding assay. | Döppenschmitt, S., et al. 1999. J Pharmacol Exp Ther. 288: 348-57. PMID: 9862789
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
rac Talinolol, 5 mg | sc-212743 | 5 mg | $232.00 |