β-defensin 20 Inhibitors
β-defensin 20 inhibitors represent a specialized class of molecules that function by modulating the activity of β-defensin 20, a member of the defensin family of antimicrobial peptides. Defensins are small, cysteine-rich proteins known for their role in host defense mechanisms, primarily through their ability to disrupt microbial membranes. β-defensin 20, like other defensins, is characterized by its β-sheet structure stabilized by disulfide bonds, which is crucial for its biological function. Inhibitors of β-defensin 20 specifically interfere with the structural or functional aspects of this peptide, preventing it from exerting its normal biological activities. These inhibitors can act in various ways, such as binding to the active sites, altering disulfide bridge formation, or inducing conformational changes that affect the protein's overall function.
The design of β-defensin 20 inhibitors often involves a deep understanding of the protein's structure, particularly the arrangement of cysteine residues and the specific binding interactions that β-defensin 20 engages in. Inhibitors may be small molecules, peptides, or other compounds that have been engineered to interact selectively with β-defensin 20. Structural biology techniques, such as X-ray crystallography or NMR spectroscopy, are frequently employed to study the three-dimensional configuration of β-defensin 20 and to identify potential binding sites for inhibitors. These inhibitors may also be screened for their ability to disrupt the peptide's activity in various biochemical assays, including binding affinity tests and functional disruption analyses. Through these approaches, researchers can gain insights into the molecular interactions between β-defensin 20 and its inhibitors, leading to a better understanding of how to effectively block its activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Flavonoid inhibiting NF-κB pathway. By suppressing NF-κB, it indirectly downregulates β-defensin 20 gene expression. This action is attributed to its interference with IκB kinase, preventing NF-κB activation and subsequent translocation to the nucleus. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
p38 MAPK inhibitor disrupting the p38 signaling cascade. Through this, it indirectly modulates β-defensin 20 expression. SB203580 targets MKK3 and MKK6, key upstream regulators of p38, leading to altered phosphorylation events that impact the β-defensin pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
PI3K inhibitor affecting the PI3K/Akt pathway. By impeding Akt activation, it indirectly influences β-defensin 20 expression. Wortmannin's interference with the PI3K pathway disrupts downstream signaling events that would normally contribute to the upregulation of β-defensin 20. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
Another PI3K inhibitor, targeting the PI3K/Akt pathway. It indirectly inhibits β-defensin 20 by blocking Akt activation, disrupting the signaling cascade that would otherwise contribute to the upregulation of β-defensin 20 gene expression. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor impacting the JNK signaling pathway. By inhibiting JNK, it indirectly downregulates β-defensin 20 gene expression. SP600125 hinders c-Jun phosphorylation, a downstream target of JNK, leading to altered transcriptional regulation of β-defensin 20. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
mTOR inhibitor affecting the mTOR signaling pathway. By inhibiting mTOR, it indirectly influences β-defensin 20 expression. Rapamycin's impact on mTOR disrupts downstream events, including the translation and transcription processes associated with β-defensin 20 regulation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Selective MEK inhibitor affecting the MAPK/ERK pathway. It indirectly modulates β-defensin 20 expression by inhibiting MEK and disrupting downstream ERK activation. This interference alters the transcriptional regulation of β-defensin 20 in response to extracellular signals. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $80.00 $212.00 $408.00 | 48 | |
TGF-β receptor inhibitor influencing the TGF-β signaling pathway. It indirectly downregulates β-defensin 20 expression by blocking TGF-β receptor activation. SB431542 prevents the downstream transduction of signals that would otherwise contribute to β-defensin 20 regulation. | ||||||
LY 303511 | 154447-38-8 | sc-202215 sc-202215A | 1 mg 5 mg | $66.00 $273.00 | 3 | |
PI3K inhibitor targeting the PI3K/Akt pathway. By blocking Akt activation, it indirectly influences β-defensin 20 expression. LY303511 disrupts the normal cascade of events within the PI3K pathway, leading to altered regulation of β-defensin 20 at the transcriptional level. | ||||||
PI 3-Kγ Inhibitor | 648450-29-7 | sc-203191 | 5 mg | $76.00 | ||
PI3Kγ inhibitor impacting the PI3K/Akt pathway. By inhibiting PI3Kγ, it indirectly downregulates β-defensin 20 gene expression. AS605240's interference with PI3Kγ disrupts downstream signaling events, altering the transcriptional regulation of β-defensin 20 in response to stimuli. | ||||||