β3-AR Activators
β3-AR (beta-3 adrenergic receptor) activators belong to a specific chemical class of compounds that have the ability to selectively stimulate the β3-adrenergic receptors found in various tissues and organs of the human body. These receptors are a subtype of adrenergic receptors, which are part of the G protein-coupled receptor family. β3-AR activators interact with and activate these receptors, leading to a cascade of intracellular signaling events. The primary characteristic that sets β3-AR activators apart from other adrenergic receptor modulators is their specificity towards β3 receptors. These receptors are primarily expressed in adipose tissue, urinary bladder, and some parts of the gastrointestinal tract.
The activation of β3-ARs by these compounds triggers a range of physiological responses. One of the key effects is the relaxation of smooth muscle in the bladder, which can be beneficial in the context of urinary incontinence. Additionally, β3-AR activators have been studied for their possible role in modulating lipid metabolism in adipose tissue, which may have implications for managing obesity and related metabolic disorders. Understanding the chemical structure and mechanisms of action of β3-AR activators is essential for exploring their roles in various physiological processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin directly stimulates adenylate cyclase, increasing cyclic AMP levels, which may enhance β3-AR expression. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
As a PPARγ agonist, rosiglitazone can upregulate β3-AR expression in adipocytes, influencing lipid metabolism. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine increases cyclic AMP levels by inhibiting phosphodiesterases, potentially leading to increased β3-AR expression. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, an adrenergic agonist, can bind to and activate β3-AR, potentially upregulating its own receptor’s expression. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
As a non-selective β-adrenergic agonist, isoproterenol may enhance β3-AR expression through activation of cyclic AMP pathways. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin can increase thermogenesis and fatty acid oxidation, potentially enhancing β3-AR expression in adipose tissue. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to influence lipid metabolism and may have a role in upregulating β3-AR expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a vitamin A derivative, can influence adipogenesis and may play a role in β3-AR expression regulation. | ||||||