Bcl-9L Inhibitors
Bcl-9L inhibitors are chemical compounds that directly or indirectly influence the function of Bcl-9L, a protein known to be a co-activator of the Wnt/β-catenin signaling pathway. Inhibitors such as ABT-737, SB216763, XAV939, IWR-1, JW74, PKF118-310, Celecoxib, Pyrvinium, Salinomycin, Quercetin, FH535, and ICG-001 can lead to the decreased functional activity of Bcl-9L through specific signaling pathways or biological processes that it is directly involved in.
For instance, ABT-737 is a Bcl-2family protein inhibitor that triggers apoptosis, which can indirectly decrease Bcl-9L's activity in the Wnt/β-catenin pathway. Similarly, SB216763 is a GSK3β inhibitor that can destabilize the β-catenin complex, leading to decreased Bcl-9L functionality. Other inhibitors like XAV939 and IWR-1 stabilize axin, a negative regulator of the Wnt/β-catenin signaling pathway, thereby suppressing the pathway and inhibiting the co-activator function of Bcl-9L. Compounds such as JW74, PKF118-310, Celecoxib, Pyrvinium, Salinomycin, Quercetin, FH535, and ICG-001 inhibit the Wnt/β-catenin signaling pathway directly, leading to a decreased co-activator function of Bcl-9L.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ABT 737 | 852808-04-9 | sc-207242 | 2.5 mg | $200.00 | 54 | |
ABT-737 is a Bcl-2 family protein inhibitor. Bcl-9L acts as a co-activator of the Wnt/β-catenin pathway. By inhibiting Bcl-2 proteins, ABT-737 can trigger apoptosis, which can indirectly decrease Bcl-9L's activity in the Wnt/β-catenin pathway. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
SB216763 is a GSK3β inhibitor. GSK3β regulates the Wnt/β-catenin signaling pathway, which Bcl-9L is involved in. By inhibiting GSK3β, SB216763 can destabilize the β-catenin complex, leading to decreased Bcl-9L functionality. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV939 is a tankyrase inhibitor that stabilizes axin, a negative regulator of the Wnt/β-catenin signaling pathway. By stabilizing axin, XAV939 can suppress the pathway and thus inhibit the co-activator function of Bcl-9L. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
IWR-1 is a Wnt pathway inhibitor that stabilizes axin, a negative regulator of the Wnt/β-catenin pathway. As Bcl-9L is a co-activator of this pathway, the inhibition of the pathway by IWR-1 can lead to decreased Bcl-9L activity. | ||||||
JW 74 | 863405-60-1 | sc-507506 | 5 mg | $168.00 | ||
JW74 is an inhibitor of the Wnt/β-catenin pathway. By inhibiting this pathway, JW74 can directly decrease the co-activator function of Bcl-9L in the pathway. | ||||||
VX 702 | 745833-23-2 | sc-361400 | 10 mg | $132.00 | 1 | |
PKF118-310 is a β-catenin/Tcf inhibitor. It disrupts the interaction between β-catenin and Tcf, thereby inhibiting the Wnt/β-catenin signaling pathway. As Bcl-9L is a co-activator of this pathway, PKF118-310 can lead to decreased Bcl-9L activity. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $224.00 $414.00 | ||
Pyrvinium is a Wnt/β-catenin pathway inhibitor. By inhibiting this pathway, Pyrvinium can directly decrease the co-activator function of Bcl-9L in the pathway. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $159.00 $236.00 $398.00 $465.00 | 1 | |
Salinomycin is a potassium ionophore that has been shown to inhibit the Wnt/β-catenin signaling pathway. By inhibiting this pathway, Salinomycin can indirectly decrease the co-activator function of Bcl-9L. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a flavonoid that has been shown to inhibit the Wnt/β-catenin signaling pathway. By inhibiting this pathway, Quercetin can indirectly decrease the co-activator function of Bcl-9L. | ||||||
β-Catenin/Tcf Inhibitor, FH535 | 108409-83-2 | sc-221398 sc-221398A | 10 mg 50 mg | $178.00 $367.00 | 7 | |
FH535 is an inhibitor of the Wnt/β-catenin and PPAR signaling pathways. By inhibiting these pathways, FH535 can directly decrease the co-activator function of Bcl-9L. | ||||||