Molecular structure of JW 74, CAS Number: 863405-60-1
JW 74 (CAS 863405-60-1)
CAS Number:
863405-60-1
Molecular Weight:
456.52
Molecular Formula:
C24H20N6O2S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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JW 74 (CAS 863405-60-1) References
- Automatic filtration and filter flush for robust online solid-phase extraction liquid chromatography. | Svendsen, KO., et al. 2011. J Sep Sci. 34: 3020-2. PMID: 21919201
- The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines. | Stratford, EW., et al. 2014. Cancer Med. 3: 36-46. PMID: 24403055
- Targeting Wnt-driven cancers: Discovery of novel tankyrase inhibitors. | Ferri, M., et al. 2017. Eur J Med Chem. 142: 506-522. PMID: 29107427
- Novel insight into the function of tankyrase. | Kim, MK. 2018. Oncol Lett. 16: 6895-6902. PMID: 30546421
- Tankyrase inhibitors as antitumor agents: a patent update (2013 - 2020). | Mehta, CC. and Bhatt, HG. 2021. Expert Opin Ther Pat. 31: 645-661. PMID: 33567917
- Dll1-Mediated Notch Signaling Drives Tumor Cell Cross-talk with Cancer-Associated Fibroblasts to Promote Radioresistance in Breast Cancer. | Nandi, A., et al. 2022. Cancer Res. 82: 3718-3733. PMID: 36007109
- Immature natural killer cells promote progression of triple-negative breast cancer. | Thacker, G., et al. 2023. Sci Transl Med. 15: eabl4414. PMID: 36888695
- Wnt Signaling Inhibitors and Their Promising Role in Tumor Treatment. | Pećina-Šlaus, N., et al. 2023. Int J Mol Sci. 24: PMID: 37047705
- Solubility of andradite, Ca3Fe2Si3O12, in a 10 mol% NaCl solution at 800 C and 10 kbar: Implications for the metasomatic origin of grandite garnet in calc-silicate granulites[J]. | Wykes J L, Newton R C, Manning C E. 2008. American Mineralogist,., 93(5-6):: 886-892.
- Emerging Role of Wnt/Beta-Catenin Signalling Pathways in Cancer Progression and Role of Small Molecule Tankyrase Inhibitors in Combating Multistage Cancers[J]. | Khatun B, Kamath V, Sathyanarayana M B,. 2021,. Current Cancer Therapy Reviews,. 17(4):: 304-311.
Inhibitor of:
Bcl-9L, BMP-2, brachyury 2, Chibby 3, Dapper2, GATA-5, GRK 3, LRP4, NKD1, RNF43, Tankyrase, and TIF1α.Activator of:
brachyury, Dkk-2, GKLF, and Six2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JW 74, 5 mg | sc-507506 | 5 mg | $168.00 |