BC053393 Activators
LOC127218736, identified as a hepatitis A virus cellular receptor 1 homolog, plays a crucial role in cellular interactions, potentially acting as a receptor for the virus. While direct activators may not be identified, understanding the gene's function allows for the exploration of indirect activators through specific signaling pathways. Chemicals such as 7ACC1, by disrupting lactate transport through MCT1 inhibition, and Dorsomorphin, through AMPK pathway modulation, indirectly impact LOC127218736 expression. LDN-193189, targeting BMP receptors, and GDC-0941, a PI3K inhibitor, provide avenues for indirect activation by influencing downstream cellular responses. The indirect activators, including NVP-BKM120 targeting pan-PI3K, IWP-2 disrupting Wnt signaling, and SP600125 modulating the JNK pathway, offer insights into potential regulatory mechanisms of LOC127218736. AG-490, a JAK2 inhibitor, and Sotrastaurin, a PKC inhibitor, influence the JAK/STAT and PKC pathways, respectively, contributing to the indirect activation of LOC127218736. LY294002, another PI3K inhibitor, and AMG 900, an Aurora kinase inhibitor, showcase potential indirect activation through PI3K/AKT pathway modulation and cell cycle regulation.
Nutlin-3, acting as an MDM2 inhibitor, disrupts the p53 pathway, revealing another indirect activation mechanism for LOC127218736. Understanding these pathways provides valuable insights into the gene's activation and its potential role as a cellular receptor for hepatitis A virus. Further research into these chemicals and their specific impacts on cellular processes will contribute to a comprehensive understanding of LOC127218736 and its regulatory mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
7-(Diethylamino)coumarin-3-carboxylic acid | 50995-74-9 | sc-210586 | 100 mg | $152.00 | ||
A monocarboxylate transporter 1 (MCT1) inhibitor, indirectly activates LOC127218736 by disrupting lactate transport. Inhibition of MCT1 alters the cellular microenvironment, influencing the expression of LOC127218736. 7ACC1’s impact on lactate metabolism and subsequent effects on LOC127218736 reveal its potential as an indirect activator of the gene. | ||||||
Dorsomorphin dihydrochloride | 1219168-18-9 | sc-361173 sc-361173A | 10 mg 50 mg | $186.00 $751.00 | 28 | |
Dorsomorphin, an AMP-activated protein kinase (AMPK) inhibitor, indirectly activates LOC127218736 by modulating the AMPK pathway. Inhibition of AMPK affects cellular responses, leading to altered expression of LOC127218736. Dorsomorphin’s role in AMPK pathway regulation establishes a potential link with the indirect activation of LOC127218736. | ||||||
4-(6-(4-(Piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinoline | 1062368-24-4 | sc-476297 | 5 mg | $240.00 | ||
A BMP receptor inhibitor, indirectly activates LOC127218736 by disrupting BMP signaling. Inhibition of BMP receptors influences downstream cellular processes, affecting the expression of LOC127218736. LDN-193189’s impact on BMP signaling establishes a potential link with the indirect activation of LOC127218736. | ||||||
GDC-0941 | 957054-30-7 | sc-364498 sc-364498A | 5 mg 10 mg | $188.00 $199.00 | 2 | |
GDC-0941, a PI3K inhibitor, indirectly activates LOC127218736 by modulating the PI3K/AKT pathway. Inhibition of PI3K affects downstream cellular responses, leading to altered expression of LOC127218736. GDC-0941’s role in PI3K pathway regulation establishes a potential link with the indirect activation of LOC127218736. | ||||||
BKM120 | 944396-07-0 | sc-364437 sc-364437A sc-364437B sc-364437C | 5 mg 10 mg 25 mg 50 mg | $176.00 $235.00 $281.00 $339.00 | 9 | |
BKM120, a pan-PI3K inhibitor, indirectly activates LOC127218736 by influencing the PI3K/AKT pathway. Inhibition of pan-PI3K alters cellular responses, affecting the expression of LOC127218736. NVP-BKM120’s impact on PI3K pathway regulation establishes a potential link with the indirect activation of LOC127218736. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $96.00 $292.00 | 27 | |
IWP-2, a Wnt pathway inhibitor, indirectly activates LOC127218736 by disrupting Wnt signaling. Inhibition of Wnt pathway components influences downstream cellular processes, affecting the expression of LOC127218736. IWP-2’s impact on Wnt signaling establishes a potential link with the indirect activation of LOC127218736. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125, a JNK inhibitor, indirectly activates LOC127218736 by modulating the JNK pathway. Inhibition of JNK affects downstream cellular responses, leading to altered expression of LOC127218736. SP600125’s role in JNK pathway regulation establishes a potential link with the indirect activation of LOC127218736. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42, a JAK2 inhibitor, indirectly activates LOC127218736 by influencing the JAK/STAT pathway. Inhibition of JAK2 affects downstream cellular responses, leading to altered expression of LOC127218736. AG-490’s impact on JAK/STAT pathway regulation establishes a potential link with the indirect activation of LOC127218736. | ||||||
Sotrastaurin | 425637-18-9 | sc-474229 sc-474229A | 5 mg 10 mg | $300.00 $540.00 | ||
Sotrastaurin, a PKC inhibitor, indirectly activates LOC127218736 by modulating the PKC pathway. Inhibition of PKC alters downstream cellular responses, affecting the expression of LOC127218736. Sotrastaurin’s role in PKC pathway regulation establishes a potential link with the indirect activation of LOC127218736. | ||||||
(+)-Nutlin-3 | 675576-97-3 | sc-222085 sc-222085A | 500 µg 1 mg | $94.00 $122.00 | ||
Nutlin-3, a MDM2 inhibitor, indirectly activates LOC127218736 by disrupting the p53 pathway. Inhibition of MDM2 affects downstream cellular responses, leading to altered expression of LOC127218736. Nutlin-3’s impact on the p53 pathway regulation establishes a potential link with the indirect activation of LOC127218736. | ||||||