BC052328 Activators
BC052328 Activators are a collection of chemical compounds that facilitate the enhancement of the functional activity of BC052328 through specific signaling pathways. Forskolin and IBMX, by increasing cAMP levels, indirectly activate PKA, leading to potential phosphorylation events that positively influence BC052328's role in its signaling cascade. Similarly, PMA, as an activator of PKC, may potentiate BC052328's function if it operates within PKC-regulated pathways. BC052328 activators constitute a chemical class specifically tailored to modulate the activity of the BC052328 protein. The initial stage in the discovery and development of these activators typically involves high-throughput screening (HTS), a process that enables the rapid evaluation of thousands to millions of compounds for their ability to influence the activity of the target protein, BC052328.
In this phase, compounds are screened using assays that have been developed to measure activity related to BC052328. These assays generally rely on detectable signals, such as fluorescence or luminescence, that correspond to changes in protein activity. Compounds that demonstrate a measurable increase in the activity of BC052328 are flagged for further investigation. To confirm the initial screening results, secondary assays, which are more specific than the primary HTS, are conducted. These assays aim to validate the compounds' activity, ensuring that the observed activation is a direct result of interaction with BC052328 and not due to off-target effects or assay artifacts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
Isobutylmethylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases which increases intracellular cAMP levels, thereby potentially enhancing "BC052328" activity by similar PKA-mediated phosphorylation pathways. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
Phorbol 12-myristate 13-acetate (PMA) is a potent activator of protein kinase C (PKC), which could enhance the activity of "BC052328" through PKC signaling cascades that intersect with "BC052328" related pathways. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore which increases intracellular calcium levels, potentially enhancing the activity of "BC052328" if it is involved in calcium-dependent signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a polyphenol that can inhibit certain kinases, potentially enhancing the activity of "BC052328" by reducing competitive signaling or through derepression of its activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor, which may enhance the activity of "BC052328" if "BC052328" functions downstream or independently of PI3K-Akt signaling by altering the balance of signaling pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAPK inhibitor and could enhance the activity of "BC052328" by shifting cellular responses away from p38 MAPK pathways if "BC052328" is part of alternative signaling routes. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor, which can enhance the activity of "BC052328" by relieving negative feedback on pathways where "BC052328" is active, if MEK is part of those regulatory loops. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor leading to increased cytosolic calcium, which can enhance "BC052328" activity if it is regulated by calcium-dependent mechanisms. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is an inhibitor of MEK1/2, potentially leading to enhanced activity of "BC052328" by reducing competition from the ERK pathway or by derepression if "BC052328" is negatively regulated by this pathway. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration, which may enhance "BC052328" activity by activating calcium-dependent proteins that interact with "BC052328". | ||||||