BC010304 Inhibitors

Family with sequence similarity 120, member A (FAM120A), also known as Ovarian cancer-associated gene 1 protein (OCA-S) or Constitutive coactivator of PPAR-gamma (CCAP), is a protein that has been implicated in a variety of cellular processes. The gene encoding FAM120A is located on human chromosome 3q13.2 and is expressed in many tissues, highlighting its potential role as a multifunctional protein.FAM120A is known to participate in RNA processing and is a component of the signal recognition particle (SRP) complex, which plays a critical role in the targeting of secretory and membrane proteins to the endoplasmic reticulum. Its involvement in the SRP complex suggests a fundamental role in the cellular protein synthesis machinery. Additionally, FAM120A has been identified as a cytoplasmic scaffold protein that affects signal transduction pathways, contributing to the regulation of cell survival, proliferation, and differentiation.

The protein has been shown to interact with the transcription factor PPAR-gamma, acting as a coactivator to modulate gene expression involved in adipogenesis and glucose metabolism, hence its alternative name CCAP. This interaction underlines its importance in metabolic processes and potential implications in metabolic disorders.In cancer biology, FAM120A has been associated with ovarian cancer, where it was initially identified. The protein's expression levels have been found to be altered in certain cancer types, suggesting a possible role in tumorigenesis or tumor progression. FAM120A's function in cancer is not fully understood, but it may influence cancer cell behavior through its impact on signaling pathways and gene expression.Research into FAM120A continues to unravel its diverse roles within the cell. As a scaffold and coactivator protein, FAM120A represents a nodal point in the cellular network, integrating signals and contributing to the regulation of cellular homeostasis. Understanding its function in greater detail could provide insights into various physiological and pathological processes.