BC005537 Activators
BC005537 Activators are a curated set of chemical compounds that execute their functions through the modulation of cellular signaling cascades, ultimately enhancing the activity of the protein BC005537. Forskolin, by increasing intracellular cAMP levels, indirectly intensifies the functional activity of BC005537 through the activation of PKA and subsequent phosphorylation of targets within BC005537's signaling network. On a similar front, IBMX raises cAMP and cGMP levels, further bolstering BC005537's role within these cyclic nucleotide-dependent pathways. The chemical repertoire for enhancing BC005537 functioning comprises compounds that interact with various molecular signaling mechanisms, each contributing to the potential elevation of BC005537 activity. Forskolin serves as a pivotal activator by increasing cAMP, subsequently activating PKA, which can phosphorylate proteins within the BC005537 regulatory network, thus enhancing BC005537's role in its associated pathways. Similarly, IBMX, by inhibiting phosphodiesterases and raising cAMP and cGMP levels, supports the amplification of BC005537's activities through cyclic nucleotide-dependent pathways.
Following the identification and confirmation of candidate activators through these meticulous screening processes, further studies are conducted to understand the interaction between these compounds and BC005537. Techniques such as X-ray crystallography or NMR spectroscopy are employed to elucidate the atomic-level details of the activators bound to BC005537. This structural information is instrumental in revealing how these compounds engage with their target and the conformational changes that underpin the enhancement of activity. Concurrently, kinetic studies using biophysical methods such as surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) provide insights into the binding efficiency and dynamics of these interactions, including how rapidly and tightly the activators bind to BC005537. These experiments are critical for understanding the precise nature of the activation mechanism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a known inhibitor of several protein kinases. By inhibiting these kinases, EGCG could reduce negative regulatory signals, thereby potentially enhancing the signaling pathways that BC005537 is part of, resulting in increased activity of BC005537. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, leading to increased cAMP and cGMP levels in cells. This elevation can enhance the BC005537 activity by promoting cAMP or cGMP-dependent signaling pathways that BC005537 may regulate. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is an activator of protein kinase C (PKC). Activation of PKC can lead to the modulation of pathways that involve BC005537, thereby enhancing its activity. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can activate calcium-dependent signaling cascades that could enhance the activity of BC005537 by impacting pathways it is directly involved in. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. Inhibition of PI3K can lead to a shift in cellular signaling balance, potentially enhancing pathways in which BC005537 is involved, thus increasing its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which are part of the MAPK pathway. Inhibition of MEK could lead to the activation of alternative pathways, potentially enhancing the activity of BC005537 if it's involved in such alternative signaling routes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 MAPK can redirect signaling to other pathways, possibly enhancing the activity of BC005537 through these alternative routes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is a calcium ionophore similar to Ionomycin, and it also increases intracellular calcium levels. This increase can lead to the activation of BC005537 by enhancing calcium-dependent signaling pathways that BC005537 is a part of. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate interacts with its receptors to activate signaling pathways that can lead to the enhancement of BC005537 activity if BC005537 is involved in these signaling pathways. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is an inhibitor of the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). By disrupting calcium homeostasis, it can activate signaling pathways that could enhance the functional activity of BC005537. | ||||||